(Z)-19-[4-(dimethylamino)butanoyloxy]heptacos-9-enedioic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (Z)-19-[4-(dimethylamino)butanoyloxy]heptacos-9-enedioic acid
• 化学式: C₃₃H₆₁NO₆
• 分子量: 567.8
• InChiKey: BKXLTNRIHBBLPB-HYXAFXHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  40
• 可旋转键数：
  31
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] NOVEL DIESTER AND TRIESTER BASED LOW MOLECULAR WEIGHT, BIODEGRADABLE CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY<br/>[FR] NOUVEAUX LIPIDES CATIONIQUES BIODÉGRADABLES DE FAIBLE MASSE MOLÉCULAIRE À BASE DE DIESTER ET TRIESTER POUR LA DÉLIVRANCE D'OLIGONUCLÉOTIDES
  申请人：MERCK SHARP & DOHME

  公开号：WO2013158579A1

  公开（公告）日：2013-10-24

  The instant invention provides for novel cationic lipids of Formula A that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain coupled with inclusion of hydrolysable functionality in the lipid chains to enhance the efficiency and tolerability of in vivo delivery of siRNA.

  本发明提供了一种新型的阳离子脂质A公式，可以与胆固醇和PEG脂质等其他脂质成分结合使用，形成含寡核苷酸的脂质纳米粒子。本发明的目的是提供一种阳离子脂质支架，其具有增强的功效，同时由于肝脏中脂质水平降低而具有较低的肝毒性。本发明采用低分子量阳离子脂质，其中一个短脂链与脂链中的可水解功能包括，以增强siRNA在体内传递的效率和耐受性。
• NOVEL DIESTER AND TRIESTER BASED LOW MOLECULAR WEIGHT, BIODEGRADEABLE CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY
  申请人：SIRNA THERAPEUTICS, INC.

  公开号：US20150133519A1

  公开（公告）日：2015-05-14

  The instant invention provides for novel cationic lipids of Formula A that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain coupled with inclusion of hydrolysable functionality in the lipid chains to enhance the efficiency and tolerability of in vivo delivery of siRNA.

  本发明提供了一种新型的阳离子脂质（化学式A），可与其他脂质成分（如胆固醇和PEG脂质）结合，形成含寡核苷酸的脂质纳米粒子。本发明的目的是提供一种阳离子脂质支架，具有增强的功效，并由于肝脏中脂质水平降低而具有较低的肝毒性。本发明采用低分子量的阳离子脂质，其中包括具有可水解功能的脂肪链，以增强siRNA的体内输送效率和耐受性。
• Diester and triester based low molecular weight, biodegradeable cationic lipids for oligonucleotide delivery
  申请人：SIRNA THERAPEUTICS, INC.

  公开号：US10307378B2

  公开（公告）日：2019-06-04

  The instant invention provides for novel cationic lipids of Formula A that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain coupled with inclusion of hydrolysable functionality in the lipid chains to enhance the efficiency and tolerability of in vivo delivery of siRNA.

  本发明提供了式 A 的新型阳离子脂质，可与胆固醇和 PEG 脂质等其他脂质成分结合使用，形成含有寡核苷酸的脂质纳米颗粒。本发明的目的是提供一种阳离子脂质支架，由于肝脏中的脂质水平较低，该支架在提高药效的同时还能降低肝脏毒性。本发明采用具有一条短脂链的低分子量阳离子脂质，并在脂链中加入可水解官能团，以提高体内递送 siRNA 的效率和耐受性。
• NOVEL DIESTER AND TRIESTER BASED LOW MOLECULAR WEIGHT, BIODEGRADABLE CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY
  申请人：Sirna Therapeutics, Inc.

  公开号：EP2838877A1

  公开（公告）日：2015-02-25
• US9402816B2
  申请人：——

  公开号：US9402816B2

  公开（公告）日：2016-08-02