4-methoxyphenyl morpholine-4-carbodithioate | 448247-56-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-methoxyphenyl morpholine-4-carbodithioate
• 英文别名: morpholine-4-carbodithioic acid 4-methoxyphenyl ester；(4-Methoxyphenyl) morpholine-4-carbodithioate
• CAS: 448247-56-1
• 化学式: C₁₂H₁₅NO₂S₂
• 分子量: 269.389
• InChiKey: APACFZWHAZEWKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  79.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  morpholine-4-carbodithioic acid 、 4-methoxybenzenediazonium tetrafluoroborate 以 水 为溶剂， 反应 2.5h， 生成 4-methoxyphenyl morpholine-4-carbodithioate
  参考文献：
  名称：

  Transition metal-free procedure for the synthesis of S-aryl dithiocarbamates using aryl diazonium fluoroborate in water at room temperature

  摘要：

  在没有任何过渡金属催化剂的情况下，通过在室温水中对芳基重氮氟硼酸盐、二硫化碳和胺进行简单的单锅缩合，开发出了一种方便、高效和绿色的 S-芳基二硫代氨基甲酸盐合成方法。该方法涉及多种取代的芳基重氮氟硼酸盐与环胺和开链胺的反应。产物通过乙醇结晶提纯，该过程不涉及任何有害溶剂。

  DOI：

  10.1039/c1gc00001b

文献信息

• Transition metal-free procedure for the synthesis of S-aryl dithiocarbamates using aryl diazonium fluoroborate in water at room temperature
  作者：Tanmay Chatterjee、Sukalyan Bhadra、Brindaban C. Ranu

  DOI：10.1039/c1gc00001b

  日期：——

  A convenient, efficient and green procedure for the synthesis of S-aryl dithiocarbamates has been developed by a simple one-pot condensation of aryl diazonium fluoroborate, carbon disulfide and amine in the absence of any transition metal catalyst in water at room temperature. The reactions of a variety of substituted aryl diazonium fluoroborates, and cyclic and open chain amines, have been addressed. The products are purified by crystallization from ethanol and the process does not involve any hazardous solvent.

  在没有任何过渡金属催化剂的情况下，通过在室温水中对芳基重氮氟硼酸盐、二硫化碳和胺进行简单的单锅缩合，开发出了一种方便、高效和绿色的 S-芳基二硫代氨基甲酸盐合成方法。该方法涉及多种取代的芳基重氮氟硼酸盐与环胺和开链胺的反应。产物通过乙醇结晶提纯，该过程不涉及任何有害溶剂。
• A magnetically recyclable iron oxide-supported copper oxide nanocatalyst (Fe₃O₄–CuO) for one-pot synthesis of S-aryl dithiocarbamates under solvent-free conditions
  作者：F. Aryanasab

  DOI：10.1039/c5ra20524g

  日期：——

  convenient and efficient procedure is reported for the synthesis of S-aryl dithiocarbamates by a simple one-pot three component Ullmann-type condensation of an amine, carbon disulfide and an aryl iodide. Magnetically separable and reusable copper oxide (Fe3O4–CuO) nanoparticles are used as a heterogeneous catalyst under base- and solvent-free conditions. Nanoparticles with an average size of 10–20 nm has

  据报道，通过胺，二硫化碳和碘代芳基的简单的一锅三组分乌尔曼型缩合来合成S-芳基二硫代氨基甲酸酯的绿色，方便且有效的方法。在无碱和无溶剂条件下，可磁分离和可重复使用的氧化铜（Fe 3 O 4 -CuO）纳米颗粒用作多相催化剂。通过一种简单的沉淀方法，已经可以容易地从便宜的廉价原料中成功地制备出平均粒径为10–20 nm的纳米粒子。使用外部磁体可以很容易地将催化剂从反应混合物中分离出来，并循环四次而不会显着降低其活性。
• Magnetically recyclable sepiolite/iron oxide/cupric oxide nanocomposite as a novel catalyst for the synthesis of <scp> <i>S</i> </scp> ‐aryl dithiocarbamates by <scp>CS</scp> bond formation
  作者：Fatemeh Hassani Bagheri、Hojatollah Khabazzadeh、Maryam Fayazi

  DOI：10.1002/jccs.202100049

  日期：2021.10

  the synthesis of S-aryl dithiocarbamates by CS bond formation through the coupling reaction of three components between secondary amines, carbon disulfide, and aryl iodides using magnetically separable and reusable sepiolite/iron oxide/cupric oxide (SEP/Fe3O4/CuO) nanocomposite as a heterogeneous catalyst. The results show that (SEP/Fe3O4/CuO) nanocomposite has good activity, and could be easily separated

  描述了一种方便有效的方法，通过使用可磁分离和可重复使用的海泡石/氧化铁/氧化铜，通过仲胺、二硫化碳和芳基碘化物之间的三种组分的偶联反应形成C  S 键形成S-芳基二硫代氨基甲酸酯。(SEP/Fe 3 O 4 /CuO) 纳米复合材料作为多相催化剂。结果表明(SEP/Fe 3 O 4/CuO) 纳米复合材料具有良好的活性，并且可以使用外部磁铁轻松地从反应混合物中分离出来。纳米复合材料的高效率与 100°С 的温度和二甲基甲酰胺 (DMF) 作为溶剂有关。的结构，形态和结晶的制备（SEP /铁的阶段3 ö 4 / CuO的）纳米复合材料的特点是傅里叶变换红外光谱（FT-IR），振动样品磁力计（VSM），扫描电子显微镜（SEM），电感耦合等离子体 (ICP) 和 X 射线粉末衍射 (XRD)。
• Transition-Metal-Free C–S Bond Formation: Aqueous Synthesis of <i>S</i>-Aryl Dithiocarbamates by The use of Stable Arenediazonium Salts Mediated by Nano-Magnetic Supported Silica Sulfonic Acid
  作者：Firouzeh Nemati、Ali Elhampour、Soghra Zulfaghari

  DOI：10.1080/10426507.2015.1024311

  日期：2015.10.3

  A convenient and transition-metal-free method for the synthesis of S-aryl dithiocarbamates based on the reaction of stable arenediazonium nano-magneto silica sulfates (ArN2+ -OSO3-SiO2@Fe3O4) with dithiocarbamic acid at room temperature was studied. Avoiding the use of any hazardous transition metal, simple procedure, low cast, and short reaction time are noteworthy advantages of this methodology.
• Reaction under Ball-Milling: Solvent-, Ligand-, and Metal-Free Synthesis of Unsymmetrical Diaryl Chalcogenides
  作者：Nirmalya Mukherjee、Tanmay Chatterjee、Brindaban C. Ranu

  DOI：10.1021/jo402071b

  日期：2013.11.1

  A convenient, efficient, and general procedure for the synthesis of diaryl chalcogenides including sulfides, selenides and tellurides has been developed by the reaction of diazonium tetrafluoroborates and diaryl dichalcogenides on the surface of alumina under ball-milling without any solvent or metal. A wide range of functionalized diaryl chalcogenides are obtained in high purity by this procedure.