Hexadecanoic acid;18-hydroxyoctadecanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Hexadecanoic acid;18-hydroxyoctadecanoic acid
• 英文别名: hexadecanoic acid;18-hydroxyoctadecanoic acid
• 化学式: C34H68O5
• 分子量: 556.9
• InChiKey: OFBDZNRQOSULIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.86
• 重原子数：
  39
• 可旋转键数：
  31
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Lipids That Increase Insulin Sensitivity And Methods Of Using The Same
  申请人：BETH ISRAEL DEACONESS MEDICAL CENTER, INC.

  公开号：US20160221925A1

  公开（公告）日：2016-08-04

  The invention provides, inter alia, fatty acyl hydroxy fatty acid (FAHFA; a novel class of estolide-related molecules) and diagnostic and treatment methods for a variety of disorders—including diabetes-related disorders, Metabolic Syndrome, polycystic ovarian syndrome, cancer, and inflammatory disorders—using them; as well as methods of screening for additional compounds that are useful in treating these disorders and/or that modulate FAHFA levels, FAHFA-mediated signaling, and FAHFA-mediated biological effects.

  该发明提供了脂肪酰羟基脂肪酸（FAHFA；一类新型的酯脂类分子）以及用于诊断和治疗各种疾病的方法，包括与糖尿病相关的疾病、代谢综合征、多囊卵巢综合征、癌症和炎症性疾病等；以及筛选可用于治疗这些疾病和/或调节FAHFA水平、FAHFA介导信号传导和FAHFA介导生物效应的其他化合物的方法。
• [EN] LIPIDS THAT INCREASE INSULIN SENSITIVITY AND METHODS OF USING THE SAME<br/>[FR] LIPIDES AUGMENTANT LA SENSIBILITÉ À L'INSULINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：BETH ISREAL DEACONESS MEDICAL CT INC

  公开号：WO2013166431A1

  公开（公告）日：2013-11-07

  The invention provides, inter alia, fatty acyl hydroxy fatty acid (FAHFA; a novel class of estolide-related molecules) and diagnostic and treatment methods for a variety of disorders- including diabetes-related disorders, Metabolic Syndrome, polycyctic ovarian syndrome, cancer, and inflammatory disorders— using them; as well as methods of screening for additional compounds that are useful in treating these disorders and/or that modulate FAHFA levels, FAHFA-mediated signaling, and FAHFA-mediated biological effects.

  这项发明提供了脂肪酰羟基脂肪酸（FAHFA；一类新型的酯脂类分子）以及用于治疗各种疾病的诊断和治疗方法，包括与糖尿病相关的疾病、代谢综合征、多囊卵巢综合征、癌症和炎症性疾病，以及使用它们的方法；以及筛选对这些疾病有用或调节FAHFA水平、FAHFA介导的信号传导和FAHFA介导的生物效应的其他化合物的方法。
• MICROFLUIDIC PRODUCTION OF BIOFUNCTIONALIZED GIANT UNILAMELLAR VESICLES FOR TARGETED INTRACELLULAR CARGO DELIVERY
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3838266A1

  公开（公告）日：2021-06-23

  The present invention relates to a method for preparation of monodisperse cell-targeting giant unilamellar vesicles based on symmetrically division of a parent polymer shell-stabilized giant unilamellar vesicle into smaller polymer shell-stabilized giant unilamellar vesicles with a diameter smaller than 10 µm using a microfluidic splitting device. The inventive method allows preparation of differently charged giant unilamellar vesicles as well as bioligand- and PEG-conjugated giant unilamellar vesicles, which are useful for targeted cellular delivery at high efficiency and specificity. A further advantage of the present invention is that the giant unilamellar vesicles can deliver huge cargos such as drug releasing porous microparticles, high amounts of in vivo imaging probes, viruses, or up-and-coming DNA origami robots.

  本发明涉及一种制备单分散细胞靶向巨型单拉美米尔囊泡的方法，其基础是利用微流体分割装置将母体聚合物壳稳定巨型单拉美米尔囊泡对称分割成直径小于10微米的较小聚合物壳稳定巨型单拉美米尔囊泡。 本发明的方法可制备不同电荷的巨型单拉米分子囊泡以及生物配体和 PEG 共轭巨型单拉米分子囊泡，这些囊泡可用于高效、特异性的细胞靶向递送。本发明的另一个优点是，巨型单拉美拉尔囊泡可以输送巨大的载体，如释放药物的多孔微颗粒、大量的体内成像探针、病毒或新兴的 DNA 折纸机器人。
• BOTTOM-UP ASSEMBLY OF SYNTHETIC EXTRACELLULAR VESICLES
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3858332A1

  公开（公告）日：2021-08-04

  The present invention relates to a method for producing synthetic extracellular vesicles comprising a lipid bilayer including at least two lipids, optionally one or more extracellular vesicle associated proteins, and optionally one or more nucleic acid molecules. The inventive synthetic extracellular vesicles are formed by emulsification using a mechanic emulsifier in the form of polymer shell stabilized synthetic extracellular vesicles. The inventive method allows producing synthetic extracellular vesicles miming the composition and function of natural extracellular vesicles. Therefore, synthetic extracellular vesicles with specific protein and nucleic acids compositions are also disclosed herein, as well as their therapeutic uses.

  本发明涉及一种生产合成细胞外囊泡的方法，该囊泡包括一个脂质双分子层，其中至少包括两种脂质、一种或多种细胞外囊泡相关蛋白，以及一种或多种核酸分子。本发明的合成细胞外囊泡是通过使用机械乳化剂乳化形成的聚合物壳稳定合成细胞外囊泡。本发明的方法可以生产出模拟天然细胞外囊泡成分和功能的合成细胞外囊泡。因此，本文还公开了具有特定蛋白质和核酸成分的合成细胞外囊泡及其治疗用途。
• Lipids that increase insulin sensitivity and methods of using the same
  申请人：Beth Israel Deaconess Medical Center, Inc.

  公开号：US10604473B2

  公开（公告）日：2020-03-31

  The invention provides, inter alia, fatty acyl hydroxy fatty acid (FAHFA; a novel class of estolide-related molecules) and diagnostic and treatment methods for a variety of disorders—including diabetes-related disorders, Metabolic Syndrome, polycystic ovarian syndrome, cancer, and inflammatory disorders—using them; as well as methods of screening for additional compounds that are useful in treating these disorders and/or that modulate FAHFA levels, FAHFA-mediated signaling, and FAHFA-mediated biological effects.

  本发明特别提供了脂肪酰羟基脂肪酸（FAHFA；一类新型的雌脂相关分子）和使用它们治疗各种疾病--包括糖尿病相关疾病、代谢综合征、多囊卵巢综合征、癌症和炎症性疾病--的诊断和治疗方法；以及筛选其他有助于治疗这些疾病和/或调节 FAHFA 水平、FAHFA 介导的信号传导和 FAHFA 介导的生物效应的化合物的方法。