butane-1,2,3,4-tetrol;(2S,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: butane-1,2,3,4-tetrol;(2S,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol
• 化学式: C16H34O15
• 分子量: 466.4
• InChiKey: YNWCXQCHILKNCV-XBLONOLSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.07
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  281
• 氢给体数：
  13
• 氢受体数：
  15

文献信息

• TABLET COMPRISING A FIRST AND SECOND REGION
  申请人：McNeil-PPC, Inc.

  公开号：EP2844221A1

  公开（公告）日：2015-03-11
• [EN] TABLET COMPRISING A FIRST AND SECOND REGION<br/>[FR] COMPRIMÉ COMPRENANT UNE PREMIÈRE ET UNE SECONDE RÉGION
  申请人：MCNEIL PPC INC

  公开号：WO2013166136A1

  公开（公告）日：2013-11-07

  In one aspect, the present invention features a tablet including a first region and a second region, wherein: (i) the first region and the second region each include at least 10%, by volume, of the tablet; (ii) the first region includes a pharmaceutically active agent and the composition of the first region is different from the composition of the second region; (iii) the first region has a density less than about 0.8 g/cc; and (iv) the first region disintegrates in the mouth when placed on the tongue in less than about 30 seconds; wherein the shape of the tablet includes two opposing major faces separated by a side wall, and the interface between the first region and the second region is along at least one major face of the tablet.