H-Asn-(1).H-Lys-OH.Ac-Ser(1)-OH.H-Pro-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Asn-(1).H-Lys-OH.Ac-Ser(1)-OH.H-Pro-OH
• 英文别名: (2S)-2-acetamido-3-[(2S)-2,4-diamino-4-oxobutanoyl]oxypropanoic acid;(2S)-2,6-diaminohexanoic acid;(2S)-pyrrolidine-2-carboxylic acid
• 化学式: C20H38N6O10
• 分子量: 522.6
• InChiKey: ITVASDRVZNRAAJ-PBCFUQCMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.33
• 重原子数：
  36
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  301
• 氢给体数：
  9
• 氢受体数：
  14

文献信息

• Substrates and inhibitors of prolyl oligopeptidase and methods of use thereof
  申请人：The Board of Regents of the University of Oklahoma

  公开号：US10155789B2

  公开（公告）日：2018-12-18

  Inhibitors of fibroblast activation protein alpha (FAP) and Prolyl Oligopeptidase (POP) are disclosed, along with their use in various therapies related to conditions, diseases, and disorders involving abnormal cell proliferation such as malignancies and angiogenesis, and in neural disorders such as Alzheimer's disease. Stalk portions of the inhibitor molecules, and substrates of FAP and POP, are also disclosed and may be used, for example, in screening methods for identifying such inhibitors.

  本研究公开了成纤维细胞活化蛋白α（FAP）和脯氨酰寡肽酶（POP）的抑制剂，以及它们在涉及异常细胞增殖（如恶性肿瘤和血管生成）的条件、疾病和紊乱以及神经紊乱（如阿尔茨海默病）的各种疗法中的用途。此外，还公开了抑制剂分子的柄部分以及 FAP 和 POP 的底物，例如，可用于识别此类抑制剂的筛选方法。
• SUBSTRATES AND INHIBITORS OF PROLYL OLIGOPEPTIDASE AND FIBROBLAST ACTIVATION PROTEIN AND METHODS OF USE
  申请人：The Board of Regents of the University of Oklahoma

  公开号：EP2844246A1

  公开（公告）日：2015-03-11
• Substrates and Inhibitors of Prolyl Oligopeptidase and Methods of Use Thereof
  申请人：The Board of Regents of the University of Oklahoma

  公开号：US20170260231A1

  公开（公告）日：2017-09-14

  Inhibitors of fibroblast activation protein alpha (FAP) and Prolyl Oligopeptidase (POP) are disclosed, along with their use in various therapies related to conditions, diseases, and disorders involving abnormal cell proliferation such as malignancies and angiogenesis, and in neural disorders such as Alzheimer's disease. Stalk portions of the inhibitor molecules, and substrates of FAP and POP, are also disclosed and may be used, for example, in screening methods for identifying such inhibitors.
• US9688722B2
  申请人：——

  公开号：US9688722B2

  公开（公告）日：2017-06-27
• [EN] SUBSTRATES AND INHIBITORS OF PROLYL OLIGOPEPTIDASE AND FIBROBLAST ACTIVATION PROTEIN AND METHODS OF USE<br/>[FR] SUBSTRATS ET INHIBITEURS DE PROLYLE OLIGOPEPTIDASE ET DE PROTÉINE D'ACTIVATION DES FIBROBLASTES ET PROCÉDÉS D'UTILISATION
  申请人：UNIV OKLAHOMA

  公开号：WO2013166438A1

  公开（公告）日：2013-11-07

  Inhibitors of fibroblast activation protein alpha (FAP) and Prolyl Oligopeptidase (POP) are disclosed, along with their use in various therapies related to conditions, diseases, and disorders involving abnormal cell proliferation such as malignancies and angiogenesis, and in neural disorders such as Alzheimer's disease. Stalk portions of the inhibitor molecules, and substrates of FAP and POP, are also disclosed and may be used, for example, in screening methods for identifying such inhibitors.