(3S,5S,6R)-3-amino-6-methyl-5-(2,2,2-trifluoro-1-phenylethyl)piperidin-2-one;hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S,5S,6R)-3-amino-6-methyl-5-(2,2,2-trifluoro-1-phenylethyl)piperidin-2-one;hydrochloride
• 化学式: C14H18ClF3N2O
• 分子量: 322.75
• InChiKey: LPRLUSKHOJKIGU-OYWHKVJQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.61
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.1
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• ALIPHATIC SPIROLACTAM CGRP RECEPTOR ANTAGONISTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2846798A2

  公开（公告）日：2015-03-18
• [EN] ALIPHATIC SPIROLACTAM CGRP RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE RÉCEPTEUR DE CGRP À BASE DE SPIROLACTAME ALIPHATIQUE
  申请人：MERCK SHARP & DOHME

  公开号：WO2013169574A2

  公开（公告）日：2013-11-14

  The present invention is directed to aliphatic spirolactam derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical\compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.