(2-phenylacetyl) (2S)-2-amino-3-phenylpropanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2-phenylacetyl) (2S)-2-amino-3-phenylpropanoate
• 化学式: C₁₇H₁₇NO₃
• 分子量: 283.32
• InChiKey: UEZFMLIGULSTSB-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• A STREAMLINED METHOD FOR ANALYTICAL VALIDATION OF BIOCHEMICALS DETECTED USING AN UNTARGETED MASS-SPECTROMETRY PLATFORM
  申请人：Metabolon, Inc.

  公开号：EP3694646A1

  公开（公告）日：2020-08-19
• TOXIN DETECTION USING STEM CELL DERIVED NEURONS
  申请人：MCNUTT Patrick

  公开号：US20150153325A1

  公开（公告）日：2015-06-04

  The present invention relates to neurons derived from a progenitor cell population, capable of forming synapse and producing neurotransmitter signals. Further, methods of producing such neurons and methods of detecting toxin activity using such neurons are disclosed.
• METHODS OF DETECTING NEUROTOXIN USING SYNAPTIC ACTIVITY
  申请人：MCNUTT Patrick

  公开号：US20150362482A1

  公开（公告）日：2015-12-17

  The present invention relates to methods of detecting neurotoxin in a sample. The methods of the present invention are highly sensitive and specific, rapid, and clinically relevant with minimal cost. The methods of the present invention use isolated neurons capable of networked synaptic activity, which allows each step of the natural toxin intoxication process to occur, mimicking the clinical manifestation of toxin intoxication. This networked synaptic activity provides rapid and highly sensitive neurotoxin detection. The methods are also directed to detecting neurotoxin neutralizing agents and neurotoxin identity.
• [EN] TOXIN DETECTION USING STEM CELL DERIVED NEURONS<br/>[FR] DÉTECTION DE TOXINE À L'AIDE DE NEURONES ISSUS DE CELLULES SOUCHES
  申请人：US OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF U S ARMY RES & MATERIAL COMMA

  公开号：WO2013170206A1

  公开（公告）日：2013-11-14

  The present invention relates to neurons derived from a progenitor cell population, capable of forming synapse and producing neurotransmitter signals. Further, methods of producing such neurons and methods of detecting toxin activity using such neurons are disclosed.
• [EN] METHODS OF DETECTING NEUROTOXIN USING SYNAPTIC ACTIVITY<br/>[FR] PROCÉDÉS DE DÉTECTION DE NEUROTOXINE À L'AIDE D'UNE ACTIVITÉ SYNAPTIQUE
  申请人：US OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF

  公开号：WO2014138663A1

  公开（公告）日：2014-09-12

  The present invention relates to methods of detecting neurotoxin in a sample. The methods of the present invention are highly sensitive and specific, rapid, and clinically relevant with minimal cost. The methods of the present invention use isolated neurons capable of networked synaptic activity, which allows each step of the natural toxin intoxication process to occur, mimicking the clinical manifestation of toxin intoxication. This networked synaptic activity provides rapid and highly sensitive neurotoxin detection. The methods are also directed to detecting neurotoxin neutralizing agents and neurotoxin identity.