N-[(E)-(4-chlorophenyl)methylideneamino]-4-methylaniline | 7628-80-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(E)-(4-chlorophenyl)methylideneamino]-4-methylaniline
• CAS: 7628-80-0
• 化学式: C₁₄H₁₃ClN₂
• 分子量: 244.724
• InChiKey: RGRCHPUWPDQFLG-MHWRWJLKSA-N

物化性质

• 熔点：
  151 °C
• 沸点：
  367.2±42.0 °C(Predicted)
• 密度：
  1.11±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  p-methylbenzenediazonium chloride 、 N-[(E)-(4-chlorophenyl)methylideneamino]-4-methylaniline 在 四丁基溴化铵 、 sodium carbonate 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 3.0h， 生成 3-p-chlorophenyl-1,5-di-p-tolylformazan
  参考文献：
  名称：

  Electrochemical Studies of Verdazyl Radicals

  摘要：

  The redox properties of verdazyl radicals are presented using cyclic voltammetry techniques. These radicals can be reversibly reduced as well as oxidized. Electron-donating and -withdrawing substituents have significant effects on the oxidation and reduction potentials as well as the cell potential (E-cell = |E-ox(degrees) - E-red(degrees)|) for these radicals; a correlation between the electron spin distribution and redox properties is developed.

  DOI：

  10.1021/ol702163a
• 作为产物：
  描述：

  4-氯苯甲醛 、 对甲基苯肼 以 乙醇 为溶剂， 反应 2.0h， 生成 N-[(E)-(4-chlorophenyl)methylideneamino]-4-methylaniline
  参考文献：
  名称：

  Electrochemical Studies of Verdazyl Radicals

  摘要：

  The redox properties of verdazyl radicals are presented using cyclic voltammetry techniques. These radicals can be reversibly reduced as well as oxidized. Electron-donating and -withdrawing substituents have significant effects on the oxidation and reduction potentials as well as the cell potential (E-cell = |E-ox(degrees) - E-red(degrees)|) for these radicals; a correlation between the electron spin distribution and redox properties is developed.

  DOI：

  10.1021/ol702163a

文献信息

• Base‐Mediated Generation of Ketenimines from Ynamides: Addition of Hydrazones to Give Acetimidohydrazides**
  作者：Capucine Mahe、Agathe C. A. D'Hollander、Kevin Cariou

  DOI：10.1002/ejoc.202200028

  日期：2022.5.13

  The addition of hydrazones onto the central carbon of the ketenimines generated in situ from N-Boc ynamides is reported. This reaction takes place under basic conditions and heating, to generate the N-arylketenimines, and gives access to a variety of acetimidohydrazides.

  报道了将腙添加到由N -Boc ynamides原位产生的酮亚胺的中心碳上。该反应在碱性条件和加热下发生，生成N-芳基烯酮亚胺，并得到多种乙酰亚氨基酰肼。
• Efficient Synthesis of Fully Substituted and Diversely Functionalized Pyrazoles through <i>p</i>‐TSA Catalyzed One‐Pot Condensation of Cyclic <i>β</i>‐Diketones, Arylglyoxals and Arylhydrazones
  作者：Arun Dhurey、Subhro Mandal、Animesh Pramanik

  DOI：10.1002/ejoc.202300770

  日期：2023.10.21

  An acid catalyzed one-pot condensation of readily available cyclic β-diketones, arylglyoxals and arylhydrazones produces a library of diversely functionalized pyrazole derivatives in excellent yield under metal-catalyst-free benign conditions.

  容易获得的环状β-二酮、芳基乙二醛和芳基腙的酸催化一锅缩合反应在无金属催化剂的良性条件下以优异的产率产生了多种官能化的吡唑衍生物库。