Methyl 3,3-bis(1-methoxyethenyl)cyclobutane-1-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 3,3-bis(1-methoxyethenyl)cyclobutane-1-carboxylate
• 英文别名: methyl 3,3-bis(1-methoxyethenyl)cyclobutane-1-carboxylate
• 化学式: C₁₂H₁₈O₄
• 分子量: 226.27
• InChiKey: ZQFMWVQFCLAGQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• CHROMANE COMPOUNDS
  申请人：Comentis, Inc.

  公开号：EP2854797A2

  公开（公告）日：2015-04-08
• [EN] CHROMANE COMPOUNDS<br/>[FR] COMPOSÉS DE CHROMANE
  申请人：ASTELLAS PHARMA INC

  公开号：WO2013181202A2

  公开（公告）日：2013-12-05

  The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by β-secretase activity, hydrolysis of a β-secretase site of a β -amyloid precursor protein, and/or β -amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.