1-(2-Nitroimidazol-1-yl)-2-piperidin-1-ylpropan-2-ol

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 1-(2-Nitroimidazol-1-yl)-2-piperidin-1-ylpropan-2-ol
• 英文别名: 1-(2-nitroimidazol-1-yl)-2-piperidin-1-ylpropan-2-ol
• 化学式: C11H18N4O3
• 分子量: 254.29
• InChiKey: KZRKREKDPQHZHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  87.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• COMPOSITIONS AND METHODS FOR NON-INVASIVE DETECTION AND TREATMENT OF HYPOXIC CELLS IN VIVO
  申请人：The Board of Trustees of the University of Arkansas

  公开号：EP2877212A2

  公开（公告）日：2015-06-03
• [EN] COMPOSITIONS AND METHODS FOR NON-INVASIVE DETECTION AND TREATMENT OF HYPOXIC CELLS IN VIVO<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR UNE DÉTECTION ET UN TRAITEMENT NON INVASIFS DE CELLULES HYPOXIQUES IN VIVO
  申请人：UNIV ARKANSAS

  公开号：WO2013188755A2

  公开（公告）日：2013-12-19

  Compositions and methods used in the non-invasive detection and/or treatment of hypoxic tissues in vivo are described. Compositions including microbubbles functionalized with one or more hypoxia targeting agents and one or more therapeutic compounds, methods of preparing the functionalized microbubbles, and methods of using the functionalized microbubbles for diagnostic and/or therapeutic applications are described, including a method for selectively determining the amount of vascular hypoxia occurring in a tissue.