4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol;hexadecanoic acid;hydrochloride

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol;hexadecanoic acid;hydrochloride
• 英文别名: 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;hexadecanoic acid;hydrochloride
• 化学式: C24H44ClNO5
• 分子量: 462.1
• InChiKey: ZTCDQIUZSWNCLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.05
• 重原子数：
  31
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  111
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Antidepressant effect of ß-hydroxy-ß-methylbutyrate
  申请人：Abbott Laboratories, Inc.

  公开号：EP2745708A1

  公开（公告）日：2014-06-25

  A method of treating or preventing depression using β-hydroxy-β-methylbutyrate (HMB) is described. The method includes administering an effective amount of HMB or a pharmaceutically acceptable salt thereof to a subject in need thereof. The HMB can be administered as part of a nutritional composition. Also provided is a method of treating or preventing a condition which can be improved or prevented by the activation of mTOR signaling by administering an effective amount of HMB or a pharmaceutically acceptable salt thereof to a subject in need thereof.

  本文描述了一种使用β-羟基-β-甲基丁酸（HMB）治疗或预防抑郁症的方法。该方法包括向有需要的受试者施用有效量的 HMB 或其药学上可接受的盐。HMB 可作为营养组合物的一部分给药。还提供了一种治疗或预防病症的方法，通过向有需要的受试者施用有效量的 HMB 或其药学上可接受的盐，可通过激活 mTOR 信号转导改善或预防病症。
• Nutritional formulations using human milk oligosaccharides for modulating inflammation
  申请人：ABBOTT LABORATORIES

  公开号：US10624916B2

  公开（公告）日：2020-04-21

  Disclosed is a nutritional composition for use in modulating or reducing inflammation in an adult or elderly individual in need thereof. In some aspects, the nutritional composition comprises a neutral human milk oligosaccharide.

  本发明公开了一种营养组合物，用于调节或减轻有需要的成年人或老年人的炎症反应。在某些方面，该营养组合物包含一种中性人乳寡糖。
• NUTRITIONAL FORMULATIONS USING HUMAN MILK OLIGOSACCHARIDES FOR MODULATING INFLAMMATION
  申请人：ABBOTT LABORATORIES

  公开号：EP2934190A1

  公开（公告）日：2015-10-28
• USE OF HMB TO IMPROVE HEALTH OUTCOMES FOR HOSPITALIZED PATIENTS
  申请人：ABBOTT LABORATORIES

  公开号：US20150119339A1

  公开（公告）日：2015-04-30

  A method of care is described that includes administering an effective amount of β-hydroxy-β-methylbutyrate (HMB) to an adult or elderly patient to decrease the risk of an adverse health event during or subsequent to hospitalization of the patient.
• USE OF HMB TO IMPROVE QUALITY OF LIFE FOR HOSPITALIZED PATIENTS
  申请人：ABBOTT LABORATORIES

  公开号：US20160106131A1

  公开（公告）日：2016-04-21

  A method of care is described that includes administering an effective amount of β-hydroxy-β-methylbutyrate (HMB) to an adult or elderly patient to improve the patient's quality of life during or after hospitalization of the patient. The improved quality of life may encompass the general health, physical health, or mental health of the patient.