1-Prop-2-ynyl-4-[[4-(trifluoromethoxy)phenyl]methoxy]benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-Prop-2-ynyl-4-[[4-(trifluoromethoxy)phenyl]methoxy]benzene
• 英文别名: 1-prop-2-ynyl-4-[[4-(trifluoromethoxy)phenyl]methoxy]benzene
• 化学式: C₁₇H₁₃F₃O₂
• 分子量: 306.28
• InChiKey: QUMWSJGBLCYKBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• METHOD FOR ACTIVATING OCT4 FOR INDUCTION OF PLURIPOTENT STEM CELLS
  申请人：Universitätsklinikum Jena

  公开号：EP2867358B1

  公开（公告）日：2018-08-08
• US9783786B2
  申请人：——

  公开号：US9783786B2

  公开（公告）日：2017-10-10
• [EN] METHOD FOR ACTIVATING OCT4 FOR INDUCTION OF PLURIPOTENT STEM CELLS<br/>[FR] MÉTHODE D'ACTIVATION DE L'OCT4 POUR L'INDUCTION DE CELLULES SOUCHES PLURIPOTENTES
  申请人：UNIVERSITAETSKLINIKUM JENA

  公开号：WO2014000814A1

  公开（公告）日：2014-01-03

  The invention relates to a method for inducing pluripotent stem cells, wherein a mammalian cell is contacted with a compound characterized by a general formula 1 wherein R1 is (CH2)mE, with E being CCH or CN and m being 0, 1, or 2, and R2 is selected from F, CI, Br, OR3 and R3, with R3 being selected from H, (CHyF2-y)n CHXF3-X, with n = 0 or 1. The invention further relates to stem cells obtained by the method of the invention, and culture media comprising the compound of the invention.