(2E,4E,6E,8E,10E)-icosa-2,4,6,8,10-pentaenoic acid;piperazine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2E,4E,6E,8E,10E)-icosa-2,4,6,8,10-pentaenoic acid;piperazine
• 化学式: C44H70N2O4
• 分子量: 691.0
• InChiKey: NZOBCHKNWZMWGJ-RHIOVGIOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.16
• 重原子数：
  50
• 可旋转键数：
  26
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  98.7
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• SALT FORMS OF FATTY ACIDS FOR THE TREATMENT OF DRY EYE
  申请人：Thetis Pharmaceuticals LLC

  公开号：US20140148464A1

  公开（公告）日：2014-05-29

  Provided herein are compositions for the treatment of dry eye, comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a fatty acid salt, and methods of use thereof.

  本文提供了用于治疗干眼症的组合物，包括一种药用可接受载体和一种脂肪酸盐的药用有效量，以及其使用方法。
• DIAMINE AND MEGLUMINE SALT FORMS OF FATTY ACIDS
  申请人：MYLARI Banavara L.

  公开号：US20140011814A1

  公开（公告）日：2014-01-09

  Provided herein are diamine salts of eicosapentaenoic acid and docosahexaenoic acid, processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and the uses of such compounds as agents for treating dyslipidemia, cardiovascular diseases such as cardiac arrhythmia, cardiac ischemia, myocardial infarction, cardiomyopathy, and stroke and obesity.

  本文提供了二元胺盐酸盐的二十碳五烯酸和二十二碳六烯酸，制备这些化合物的过程，包含这些化合物的药物组合物，并将这些化合物用作治疗失调脂质血症、心血管疾病（如心律失常、心肌缺血、心肌梗塞、心肌病和中风）和肥胖症的药物。
• [EN] DIAMINE AND MEGLUMINE SALT FORMS OF FATTY ACIDS<br/>[FR] FORMES SALINES DIAMINE ET MÉGLUMINE D'ACIDES GRAS
  申请人：THETIS PHARMACEUTICALS LLC

  公开号：WO2014008379A2

  公开（公告）日：2014-01-09

  Provided herein are diamine salts of eicosapentaenoic acid and docosahexaenoic acid, processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and the uses of such compounds as agents for treating dyslipidemia, cardiovascular diseases such as cardiac arrhythmia, cardiac ischemia, myocardial infarction, cardiomyopathy, and stroke and obesity.