(3S)-3-amino-4-[(1-amino-1-carboxyethyl)amino]-4-oxobutanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S)-3-amino-4-[(1-amino-1-carboxyethyl)amino]-4-oxobutanoic acid
• 化学式: C₇H₁₃N₃O₅
• 分子量: 219.2
• InChiKey: YRTDDSMBWSRRLW-NSJQTVLISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  156
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• O-LINKED CARBOHYDRATE-MODIFIED INSULIN ANALOGUES
  申请人：Case Western Reserve University

  公开号：EP2877200B1

  公开（公告）日：2019-05-08
• US9624287B2
  申请人：——

  公开号：US9624287B2

  公开（公告）日：2017-04-18
• [EN] O-LINKED CARBOHYDRATE-MODIFIED INSULIN ANALOGUES<br/>[FR] ANALOGUES DE L'INSULINE MODIFIÉS PAR UN GLUCIDE RELIÉ À L'OXYGÈNE
  申请人：WEISS MICHAEL

  公开号：WO2014015078A1

  公开（公告）日：2014-01-23

  An insulin analogue comprises an insulin B-chain polypeptide modified with an O-linked monosaccaride pyranoside adduct at the side chain of residue B27 or an O-linked monosaccaride pyranoside adduct at the side chain of residue B30, or both, where the positions are recited relative to human insulin. The monosaccaride may be a manopyranoside, an N-acetyl-galactopyranoside, or a glucopyranoside. The insulin analogue may additionally comprise containing a foreshortened B-chain polypeptide lacking residues B1-B3, an extension of 1 or 2 Glu residues on the carboxy terminal end of the B-chain polypeptide, an extension of ornithine at the carboxy-terminal end of the B-chain, the substitutions Lys at position B28 and Pro at position B29, an ornithine substitution at position B29, or combinations thereof. The analogue may be an analogue of a mammalian insulin, such as human insulin. A method of treating a patient comprises administering a physiologically effective amount of the insulin analogue.