1,1-Bis[3-(4-fluorophenoxy)propyl]guanidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,1-Bis[3-(4-fluorophenoxy)propyl]guanidine
• 英文别名: 1,1-bis[3-(4-fluorophenoxy)propyl]guanidine
• 化学式: C₁₉H₂₃F₂N₃O₂
• 分子量: 363.4
• InChiKey: CABAZMRPBJLXBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  71.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME
  申请人：Drexel University

  公开号：EP2874997A2

  公开（公告）日：2015-05-27
• [EN] NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME<br/>[FR] NOUVEAUX LIGANDS DU RÉCEPTEUR SIGMA ET PROCÉDÉS DE MODULATION DE L'HOMÉOSTASE DE PROTÉINE CELLULAIRE À L'AIDE DE CEUX-CI
  申请人：PHILADELPHIA HEALTH & EDUCATIO

  公开号：WO2014015157A2

  公开（公告）日：2014-01-23

  The present invention includes compounds useful in preventing, treating or ameliorating Sigma-related disorders or diseases. The compounds of the invention may modulate cellular protein homeostasis, which includes: translation initiation, folding, processing, transport, and degradation (including ubiquitin selective autophagy) of proteins. The present invention also includes methods of preventing, treating or ameliorating a Sigma-related disorder or disease in a subject in need thereof, the method comprising administering to the subject an effective amount of a Sigma-modulating compound. The present invention also includes methods of preventing, treating or ameliorating a Sigma-related disorder or disease in a subject in need thereof, the method comprising administering to the subject an effective amount of a Sigma-modulating compound, further comprising administering an effective amount of a compound that inhibits the ubiquitin proteasome system (UPS) and/or autophagic survival pathways.