Calcium;2-fluoroprop-2-enoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Calcium;2-fluoroprop-2-enoate
• 英文别名: calcium;2-fluoroprop-2-enoate
• 化学式: C6H4CaF2O4
• 分子量: 218.17
• InChiKey: NRTXADDPBIKAKB-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -1.94
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• COMPOSITIONS COMPRISING CROSSLINKED CATION-BINDING POLYMERS AND USES THEREOF
  申请人：Relypsa, Inc.

  公开号：US20150183908A1

  公开（公告）日：2015-07-02

  The present disclosure relates generally to crosslinked cation-binding polymers comprising monomers containing carboxylic acid groups and pKa decreasing groups, wherein the polymer contains i) calcium cations that are counterions to about 5% to about 75% of the carboxylic acid groups in the polymer; or ii) calcium cations and magnesium cations that are counterions to about 5% to about 75% of the carboxylic acid groups in the polymer, wherein the magnesium cations are counterions to no more than about 35% of the carboxylate groups in the polymer. The present disclosure also relates to methods of preparation of the poly mers, and compositions, formulations, and dosage forms containing the polymers, and methods of using the polymers, compositions, formulations, and/or dosage forms to treat various diseases or disorders.

  本公开涉及交联阳离子结合聚合物，该聚合物包含含有羧酸基和pKa降低基的单体，其中聚合物包含i）钙阳离子，其是聚合物中约5％至约75％的羧酸基的对离子；或ii）钙阳离子和镁阳离子，其是聚合物中约5％至约75％的羧酸基的对离子，其中镁阳离子对聚合物中的羧酸盐基不超过约35％。本公开还涉及聚合物的制备方法，以及含有聚合物的组合物、配方和剂量形式，以及使用聚合物、组合物、配方和/或剂量形式治疗各种疾病或障碍的方法。
• Process for preparation of patiromer
  申请人：Solara Active Pharma Sciences Limited

  公开号：US11142603B2

  公开（公告）日：2021-10-12

  The present application relates to a commercially viable process for the preparation of Patiromer, a crosslinked polymer. More particularly the present application relates to a commercially viable process for the preparation of Patiromer sorbitex calcium, an active ingredient useful in the treatment of hyperkalemia.

  本申请涉及一种制备交联聚合物 Patiromer 的商业可行工艺。更具体地说，本申请涉及一种制备 Patiromer 山梨糖钙的商业上可行的工艺，山梨糖钙是一种用于治疗高钾血症的活性成分。
• PROCESS FOR DRYING POLYMERIC MATERIALS
  申请人：DPx Fine Chemicals Austria GmbH & Co KG

  公开号：EP2882798A1

  公开（公告）日：2015-06-17
• Process for Preparation of Patiromer
  申请人：Solara Active Pharma Sciences Limited

  公开号：US20190352442A1

  公开（公告）日：2019-11-21

  The present application relates to a commercially viable process for the preparation of Patiromer, a crosslinked polymer. More particularly the present application relates to a commercially viable process for the preparation of Patiromer sorbitex calcium, an active ingredient useful in the treatment of hyperkalemia.
• US9982940B2
  申请人：——

  公开号：US9982940B2

  公开（公告）日：2018-05-29