(10E)-9,16-dihydroxyoctadeca-10,17-dien-12,14-diynoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (10E)-9,16-dihydroxyoctadeca-10,17-dien-12,14-diynoic acid
• 化学式: C₁₈H₂₄O₄
• 分子量: 304.4
• InChiKey: FERPWRANYSRDCY-GXDHUFHOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Composition comprising Dendropanax morbifera extract or compound derived therefrom as active ingredient for preventing and treating benign prostatic hyperplasia
  申请人：INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY

  公开号：US10130668B2

  公开（公告）日：2018-11-20

  Provided is a use of Dendropanax morbifera extract as an agent for preventing and treating benign prostatic hyperplasia, and more particularly, a composition for preventing and treating benign prostatic hyperplasia and a functional health food for preventing and reducing the effects of benign prostatic hyperplasia, in which the composition and food include, as an active ingredient, a Dendropanax morbifera extract or a compound which is isolated from the extract and then purified.

  本发明提供了一种石斛提取物作为预防和治疗良性前列腺增生的药物的用途，更具体地说，是一种用于预防和治疗良性前列腺增生的组合物和一种用于预防和减轻良性前列腺增生影响的功能性保健食品，其中组合物和食品包括作为有效成分的石斛提取物或从提取物中分离并纯化的化合物。
• COMPOSITION COMPRISING DENDROPANAX MORBIFERAEXTRACT OR COMPOUND DERIVED THEREFROM AS ACTIVE INGREDIENT FOR PREVENTING AND TREATING BENIGN PROSTATIC HYPERPLASIA
  申请人：INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY

  公开号：US20150182571A1

  公开（公告）日：2015-07-02

  Provided is a use of Dendropanax morbifera extract as an agent for preventing and treating benign prostatic hyperplasia, and more particularly, a composition for preventing and treating benign prostatic hyperplasia and a functional health food for preventing and reducing the effects of benign prostatic hyperplasia, in which the composition and food include, as an active ingredient, a Dendropanax morbifera extract or a compound which is isolated from the extract and then purified. The Dendropanax morbifera extract and the compound isolated from the extract have been demonstrated to be capable of effectively preventing and treating benign prostatic hyperplasia through a mechanism for inhibiting the androgen receptor signaling that induces benign prostatic hyperplasia. Therefore, the Dendropanax morbifera extract and the compound isolated from the extract according to the present invention can be effectively used in the production of medicines and functional foods capable of preventing, treating, and reducing the effects of benign prostatic hyperplasia and prostate cancer.
• [EN] COMPOSITION COMPRISING DENDROPANAX MORBIFERA EXTRACT OR COMPOUND DERIVED THEREFROM AS ACTIVE INGREDIENT FOR PREVENTING AND TREATING BENIGN PROSTATIC HYPERPLASIA<br/>[FR] COMPOSITION, COMPRENANT UN EXTRAIT DE DENDROPANAX MORBIFERA OU UN COMPOSÉ DÉRIVÉ DE CELUI-CI COMME PRINCIPE ACTIF, DESTINÉE À LA PRÉVENTION ET AU TRAITEMENT DE L'HYPERPLASIE PROSTATIQUE BÉNIGNE
  申请人：UNIV CHOSUN IACF

  公开号：WO2014014177A1

  公开（公告）日：2014-01-23

  본 발명은 전립선 비대증의 예방 및 치료제로서 황칠나무 추출물의 용도에 관한 것으로서, 보다 상세하게 본 발명은 황칠나무 추출물 및 상기 추출물로부터 분리 및 정제한 화합물을 유효성분으로 포함하는 전립선 비대증의 예방 및 치료용 조성물과 전립선 비대증의 예방 및 개선용 기능성 건강식품에 관한 것이다. 본 발명에 따른 황칠나무 추출물 및 상기 추출물로부터 분리한 화합물은 전립선 비대 효과를 유발시키는 안드로젠 수용체 시그럴닝을 억제하는 기전을 통해 전립선 비대증을 효과적으로 예방 및 치료할 수 있음을 규명하였다. 따라서 본 발명에 따른 황칠나무 추출물 및 상기 추출물로부터 분리된 화합물은 전립선 비대증 및 전립선암을 예방, 치료 및 개선할 수 있는 의약품 및 기능성 식품의 제조에 유용하게 사용할 수 있는 효과가 있다.