(E)-4-[(E)-3-carboxy-2,3-difluoroprop-2-enoyl]oxy-2,3-difluoro-4-oxobut-2-enoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (E)-4-[(E)-3-carboxy-2,3-difluoroprop-2-enoyl]oxy-2,3-difluoro-4-oxobut-2-enoic acid
• 化学式: C₈H₂F₄O₇
• 分子量: 286.09
• InChiKey: NOBZXKROLMRDKM-ZPUQHVIOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• COMPOSITIONS COMPRISING CROSSLINKED CATION-BINDING POLYMERS
  申请人：Relypsa, Inc.

  公开号：EP2874633A1

  公开（公告）日：2015-05-27
• [EN] COMPOSITIONS COMPRISING CROSSLINKED CATION-BINDING POLYMERS<br/>[FR] COMPOSITIONS COMPRENANT DES POLYMÈRES RÉTICULÉS DE LIAISON À DES CATIONS
  申请人：SORBENT THERAPEUTICS INC

  公开号：WO2014015240A1

  公开（公告）日：2014-01-23

  The present disclosure relates generally to compositions comprising a crosslinked cation-binding polymer comprising monomers containing carboxylic acid groups and pKa decreasing groups, including electron-withdrawing substituents such as halide atoms (e.g., fluorine), and a base, wherein the polymer optionally contains less than about 20,000 ppm of non-hydrogen cations, and wherein the base is present in an amount sufficient to provide from about 0.2 equivalents to about 0.95 equivalents of base per equivalent of carboxylic acid groups in the polymer. The present disclosure also relates to methods of preparation of said compositions and methods of using said compositions to treat various diseases or disorders.