Hept-4-yne-1,2,3-triol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Hept-4-yne-1,2,3-triol
• 英文别名: hept-4-yne-1,2,3-triol
• 化学式: C₇H₁₂O₃
• 分子量: 144.17
• InChiKey: ROIDZMLUHWWGLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] HEXAHYDROPYRROLOTHIAZINE COMPOUNDS<br/>[FR] COMPOSÉS D'HEXAHYDROPYRROLOTHIAZINE
  申请人：EISAI R&D MAN CO LTD

  公开号：WO2014013076A1

  公开（公告）日：2014-01-23

  A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R9 are as defined in the specification and which compound has an Αβ production inhibitory effect and may be useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Αβ and typified by Alzheimer-type dementia (AD) or Down's syndrome.

  公式（I）的化合物或其药用盐，其中R1至R9如规范中定义，并且该化合物具有抑制Αβ产生的效果，可能作为一种预防或治疗剂用于由Αβ引起的以阿尔茨海默症（AD）或唐氏综合征为特征的神经退行性疾病。
• ANTISPASMODIC 1,2-DIOLS AND 1,2,3-TRIOLS
  申请人：Prima Innovations LLC

  公开号：EP2854782A1

  公开（公告）日：2015-04-08
• [EN] ANTISPASMODIC 1,2-DIOLS AND 1,2,3-TRIOLS<br/>[FR] 1,2-DIOLS ET 1,2,3-TRIOLS ANTISPASMODIQUES
  申请人：PRIMA INNOVATIONS LLC

  公开号：WO2013181084A1

  公开（公告）日：2013-12-05

  The present invention is directed to pharmaceutical compositions comprising antispasmodic C4-C8aliphatic-l,2-diols and C4-C8aliphatic-l,2,3-triols and their use to relieve the spasms associated with pain. These agents may be administered topically or orally and may be combined with anti-inflammatory agents such as a non-steroidal anti-inflammatory drug or a corticosteroid. Administration of the C4-C8aliphatic-l,2-diols and C4-C8aliphatic-l,2,3-triols with vitamin D3 is indicated for conditions such as bone loss, weight gain and autoimmune diseases such as lupus and rheumatoid arthritis.