3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol;(Z)-octadec-9-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol;(Z)-octadec-9-enoic acid
• 化学式: C32H57NO3
• 分子量: 503.8
• InChiKey: DBSODHKRMCZILN-VYYWTXNMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.19
• 重原子数：
  36
• 可旋转键数：
  20
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• PHARMACEUTICAL PATCH FOR TRANSDERMAL ADMINISTRATION OF TAPENTADOL
  申请人：Grünenthal GmbH

  公开号：EP2872126A1

  公开（公告）日：2015-05-20
• Pharmaceutical Patch for Transdermal Administration of Tapentadol
  申请人：Gruenenthal GmbH

  公开号：US20150148759A1

  公开（公告）日：2015-05-28

  The invention relates to a pharmaceutical patch for transdermal administration of the pharmacologically active ingredient Tapentadol or a physiologically acceptable salt thereof, the patch comprising a surface layer, an adhesive layer which comprises a pressure sensitive adhesive and at least a portion of the total amount of the pharmacologically active ingredient that is contained in the pharmaceutical patch, and a removable protective layer, wherein the adhesive layer is located between the surface layer and the removable protective layer.
• [EN] PHARMACEUTICAL PATCH FOR TRANSDERMAL ADMINISTRATION OF TAPENTADOL<br/>[FR] PATCH PHARMACEUTIQUE POUR L'ADMINISTRATION TRANSDERMIQUE DE TAPENTADOL
  申请人：GRUENENTHAL GMBH

  公开号：WO2014012653A1

  公开（公告）日：2014-01-23

  The invention relates to a pharmaceutical patch for transdermal administration of the pharmacologically active ingredient Tapentadol or a physiologically acceptable salt thereof, the patch comprising a surface layer, an adhesive layer which comprises a pressure sensitive adhesive and at least a portion of the total amount of the pharmacologically active ingredient that is contained in the pharmaceutical patch, and a removable protective layer, wherein the adhesive layer is located between the surface layer and the removable protective layer.