(2S)-2-amino-6-(cyclopentanecarbonylamino)hexanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-6-(cyclopentanecarbonylamino)hexanoic acid
• 化学式: C₁₂H₂₂N₂O₃
• 分子量: 242.31
• InChiKey: FQFIGHYUHCWZRZ-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• REAGENTS AND METHODS FOR REPLICATION, TRANSCRIPTION, AND TRANSLATION IN SEMI-SYNTHETIC ORGANISMS
  申请人：The Scripps Research Institute

  公开号：US20200392550A1

  公开（公告）日：2020-12-17

  Disclosed herein are compositions, methods, cells, engineered microorganisms, and kits for increasing the production of proteins or polypeptides comprising one or more unnatural amino acids. Further provided are compositions, cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism.

  本文揭示了一种用于增加含有一个或多个非天然氨基酸的蛋白质或多肽的生产的组合物、方法、细胞、工程微生物和试剂盒。此外，还提供了一种用于增加编码非天然氨基酸的非天然核酸在工程细胞或半合成生物体中的保留的组合物、细胞、工程微生物和试剂盒。
• PIF1-LIKE HELICASE AND APPLICATION THEREOF
  申请人：Qitan Technology Ltd., Beijing

  公开号：EP4063382A9

  公开（公告）日：2022-11-16

  A modified Pifl-like helicase, a construct containing a Pifl-like helicase, and an application thereof in characterizing a target polynucleotide or controlling the movement of a target polynucleotide passing through pores. The present invention also relates to a method for characterizing a target polynucleotide or controlling the movement of a target polynucleotide passing through pores. The Pifl-like helicase can effectively control the movement of a polynucleotide passing through pores and increase the accuracy of a chain sequencing process.

  一种改进的类 Pifl 螺旋酶、一种含有类 Pifl 螺旋酶的构建体及其在表征目标多核苷酸或控制目标多核苷酸穿过孔隙的运动中的应用。本发明还涉及一种表征目标多核苷酸或控制目标多核苷酸穿过孔隙的方法。Pifl 样螺旋酶可有效控制穿过孔隙的多核苷酸的运动，提高链测序过程的准确性。
• Method for attaching one or more polynucleotide binding proteins to a target polynucleotide
  申请人：Oxford Nanopore Technologies Ltd.

  公开号：US10385389B2

  公开（公告）日：2019-08-20

  The invention relates to new methods of attaching one or more polynucleotide binding proteins to a target polynucleotide. The invention also relates to new methods of characterizing target polynucleotides.

  本发明涉及将一种或多种多核苷酸结合蛋白连接到目标多核苷酸上的新方法。本发明还涉及表征目标多核苷酸的新方法。
• Cytokine conjugates for the treatment of proliferative and infectious diseases
  申请人：Synthorx, Inc.

  公开号：US10610571B2

  公开（公告）日：2020-04-07

  Disclosed herein are interleukin (IL) conjugates (e.g., IL-2 conjugates) and use in the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).

  本文公开了白细胞介素（IL）共轭物（如IL-2共轭物）及其在治疗一种或多种适应症中的用途。本文还描述了包含一种或多种白细胞介素共轭物（如 IL-2 共轭物）的药物组合物和试剂盒。
• Modified helicases
  申请人：Oxford Nanopore Technologies Ltd.

  公开号：US10724018B2

  公开（公告）日：2020-07-28

  The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

  本发明涉及一种表征目标多核苷酸的新方法。该方法使用一个孔和一个 Dda 螺旋酶。螺旋酶控制目标多核苷酸通过孔道。本发明还涉及经修饰的 Dda 螺旋酶，它可用于控制多核苷酸的运动，尤其适用于多核苷酸的测序。