Ethyl 2-cyano-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylbutanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Ethyl 2-cyano-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylbutanoate
• 英文别名: ethyl 2-cyano-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylbutanoate
• 化学式: C₁₃H₂₁NO₄
• 分子量: 255.31
• InChiKey: OYSUQGKAWMFJFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  68.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] D-AMINO ACID COMPOUNDS FOR LIVER DISEASE<br/>[FR] COMPOSÉS D'ACIDE D-AMINÉ CONTRE LES MALADIES HÉPATIQUES
  申请人：IDENIX PHARMACEUTICALS INC

  公开号：WO2013177219A1

  公开（公告）日：2013-11-28

  Provided herein are compounds comprising a D-amino acid, compositions and methods for the treatment of liver disease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了包含D-氨基酸的化合物、用于治疗肝脏疾病和状况（包括HCV感染）的组合物和方法。在某些实施例中，披露了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒剂联合使用。
• DEUTERATED AMINOGLYCIDAL COMPOUNDS
  申请人：Gant Thomas G.

  公开号：US20090182057A1

  公开（公告）日：2009-07-16

  Provided herein are substituted aminoglycidyl compounds of Formula (1), processes of preparation, and pharmaceutical compositions thereof and methods of their use for treating, preventing, or ameliorating one or more symptoms of a social anxiety disorder, an anxiety disorder, hyperthyroidism, tremor, glaucoma, hypertension, coronary artery bypass graft, chronic stable angina, atrial arrhythmia, migraine, bleeding esophageal varices, hypertrophic subaortic stenosis, heart failure, post-myocardial infarction, decreased left ventricular function after recent myocardial infarction, and/or any disorder ameliorated by beta adrenergic receptor modulators.

  本文提供了一种式子为（1）的取代氨基环氧丙烷化合物，其制备方法，以及其制药组合物和用于治疗、预防或缓解社交焦虑症、焦虑症、甲状腺功能亢进、震颤、青光眼、高血压、冠状动脉搭桥手术、慢性稳定型心绞痛、心房心动过速、偏头痛、食管静脉曲张出血、肥厚性主动脉瓣下狭窄、心力衰竭、心肌梗死后、近期心肌梗死后左心室功能下降和/或任何通过β肾上腺素能受体调节剂缓解的疾病的治疗方法。
• D-AMINO ACID COMPOUNDS FOR LIVER DISEASE
  申请人：IDENIX Pharmaceuticals, Inc.

  公开号：EP2852603A1

  公开（公告）日：2015-04-01
• AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV
  申请人：IDENIX Pharmaceuticals, Inc.

  公开号：EP2970357A1

  公开（公告）日：2016-01-20
• [EN] AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV<br/>[FR] PRONUCLÉOTIDES DE PHOSPHORAMIDATE D'ACIDE AMINÉ DE 2'-CYANO, AZIDO ET AMINO NUCLÉOSIDES POUR LE TRAITEMENT DU VIRUS DE L'HÉPATITE C (VHC)
  申请人：IDENIX PHARMACEUTICALS INC

  公开号：WO2014160484A1

  公开（公告）日：2014-10-02

  Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2'-cyano, azido or amino nucleosides according to or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein Base, W, R1, R2, R10, and R11 are as described herein.