(Z)-but-2-enedioate;pyrrolidin-1-ium

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (Z)-but-2-enedioate;pyrrolidin-1-ium
• 化学式: C12H22N2O4
• 分子量: 258.31
• InChiKey: BAENGVDXAUFQAY-KSBRXOFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.27
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• ASYMMETRICAL REVERSIBLE NEUROMUSCULAR BLOCKING AGENTS OF ULTRA-SHORT, SHORT, OR INTERMEDIATE DURATION
  申请人：Cornell University

  公开号：EP2867219A2

  公开（公告）日：2015-05-06
• [EN] ASYMMETRICAL REVERSIBLE NEUROMUSCULAR BLOCKING AGENTS OF ULTRA-SHORT, SHORT, OR INTERMEDIATE DURATION<br/>[FR] AGENTS BLOQUANTS NEUROMUSCULAIRES ASYMÉTRIQUES RÉVERSIBLES DE DURÉE ULTRA-COURTE, COURTE OU INTERMÉDIAIRE
  申请人：SAVARESE JOHN J

  公开号：WO2014005122A2

  公开（公告）日：2014-01-03

  We describe ultra-short, short, and intermediate duration neuromuscular blocking compounds, reversible by cysteine or similar compounds, that are bisquatemary diesters of chlorofumaric, fumaric, or maleic acids where the quaternary groups are very different, creating a highly asymmetrical molecule where one quaternary includes an isoquinolinium ring system and the other includes a morpholinium, piperidinium, piperazinium, or pyrrolidinium system, pharmaceutical compositions, methods to use such compounds and compositions, and kits.
• [EN] REVERSAL OF CYSTEINE-INACTIVATED NEUROMUSCULAR BLOCKING DRUGS WITH COMBINATIONS OF REVERSAL AGENTS<br/>[FR] INVERSION DES EFFETS D'UN MÉDICAMENT DE BLOCAGE NEUROMUSCULAIRE INACTIVÉ PAR LA CYSTÉINE AU MOYEN D'ASSOCIATIONS D'AGENTS D'INVERSION
  申请人：UNIV CORNELL

  公开号：WO2014210369A2

  公开（公告）日：2014-12-31

  We provide methods and kits to reverse neuromuscular block caused by a cysteine-inactivated neuromuscular blocking drug, comprising administering to said subject a combination of a cysteine-like agent and an acetylcholinesterase inhibitor. An antimuscarinic agent may also be administered to said subject.