2,2-Bis[[2-(propoxymethoxy)acetyl]amino]propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,2-Bis[[2-(propoxymethoxy)acetyl]amino]propanoic acid
• 英文别名: 2,2-bis[[2-(propoxymethoxy)acetyl]amino]propanoic acid
• 化学式: C₁₅H₂₈N₂O₈
• 分子量: 364.39
• InChiKey: LZTSNAZBVQVCHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  25
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  132
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• LIGANDS FOR ANTIBODY AND FC-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMOTOGRAPHY IV
  申请人：GRAFFINITY PHARMACEUTICALS GMBH

  公开号：US20160009760A1

  公开（公告）日：2016-01-14

  The present invention relates to the use, for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material, the ligand being represented by formula (I) L-(Sp) v -Ar 1 —Am—Ar 2 (I) wherein L, SP, Ar 1 , AM, Ar 2 and v are defined herein.

  本发明涉及使用含有配体取代基质来亲和纯化抗体或抗体片段，所述基质包括支持材料和至少一个与支持材料共价结合的配体，所述配体由式(I)所表示：L-(SP)v-Ar1—AM—Ar2(I)，其中L、SP、Ar1、AM、Ar2和v在此处有定义。
• US9745339B2
  申请人：——

  公开号：US9745339B2

  公开（公告）日：2017-08-29
• [EN] LIGANDS FOR APHERESIS AND IMMUNOABSORPTION<br/>[FR] LIGANDS POUR APHÉRÈSE ET IMMUNOABSORPTION
  申请人：GRAFFINITY PHARMACEUTICALS GMBH

  公开号：WO2014020152A1

  公开（公告）日：2014-02-06

  The present invention relates to a method for separating one or more proteins from plasma by immunoadsorption IA, comprising • contacting the plasma with a ligand-substituted matrix; and • removing the plasma from the ligand-substituted matrix; • wherein the ligand-substituted matrix comprises a support material and at least one ligand covalently bonded to the support material.