N-(3-morpholin-4-ylpropyl)-2-phenylpyrrole-1-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: N-(3-morpholin-4-ylpropyl)-2-phenylpyrrole-1-carboxamide
• 化学式: C₁₈H₂₃N₃O₂
• 分子量: 313.4
• InChiKey: AKLAOSVGOKRJGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOUNDS WITH TRPV4 ACTIVITY, COMPOSITIONS AND ASSOCIATED METHODS THEREOF
  申请人：The University of Utah Research Foundation

  公开号：EP2847164A1

  公开（公告）日：2015-03-18
• [EN] COMPOUNDS WITH TRPV4 ACTIVITY, COMPOSITIONS AND ASSOCIATED METHODS THEREOF<br/>[FR] COMPOSÉS AYANT UNE ACTIVITÉ TRPV4, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS DE CES COMPOSÉS
  申请人：UNIV UTAH RES FOUND

  公开号：WO2013169396A1

  公开（公告）日：2013-11-14

  Compounds, compositions and methods useful for treating ocular diseases are provided. In particular, antagonists of TRPV4, their synthesis, pharmaceutical compositions thereof and methods of treating ocular diseases such as glaucoma, are disclosed. Compounds of the invention include N-(3-(trifluoromethyl)phenyl )-2-methyl-1-(3-morpholinopropyl )-5-phenyl-1 H-pyrrole-3-carboxamide, as well as other 2-phenyl-pyrrole carboxamide derivates and indole carboxamide derivatives.