Imidazo[2,1-b][1,3]oxazole-5-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Imidazo[2,1-b][1,3]oxazole-5-carboxamide
• 英文别名: imidazo[2,1-b][1,3]oxazole-5-carboxamide
• 化学式: C₆H₅N₃O₂
• 分子量: 151.12
• InChiKey: ILFMSEDOWWJVJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 5,5-HETEROAROMATIC ANTI-INFECTIVE COMPOUNDS
  申请人：UNIVERSITY OF NOTRE DAME DU LAC

  公开号：US20150210715A1

  公开（公告）日：2015-07-30

  The invention provides a series of 5,5-heteroaromatic compounds, syntheses thereof, compositions thereof, and methods of using such compounds and compositions. Various embodiments provide methods of killing and/or inhibiting the growth of M. tuberculosis and/or M. avium , and methods of treating, preventing, and/or ameliorating M. tuberculosis and/or M. avium infections in a subject. In various embodiments, the 5,5-heteroaromatic compound is N-(4-(4-chlorophenoxy)benzyl)-2,6-dimethylimidazo[2,1-b]thiazole-5-carboxamide.

  该发明提供了一系列5,5-杂环芳烃化合物，其合成方法，组合物以及使用这些化合物和组合物的方法。各种实施方式提供了杀灭和/或抑制结核分枝杆菌和/或分枝杆菌的生长的方法，以及治疗、预防和/或改善受试者体内结核分枝杆菌和/或分枝杆菌感染的方法。在各种实施方式中，5,5-杂环芳烃化合物为N-(4-(4-氯苯氧基)苄基)-2,6-二甲基咪唑[2,1-b]噻唑-5-羧酰胺。
• CAR ACTIVATOR AGENTS FOR CYCLOPHOSPHAMIDE-BASED TREATMENTS OF CANCER
  申请人：UNIVERSITY OF MARYLAND, BALTIMORE

  公开号：US20200352915A1

  公开（公告）日：2020-11-12

  The invention relates to selective small molecule human constitutive androstane receptor (hCAR) activators of Formula (I) or (II), pharmaceutical compositions thereof, and use thereof for the treatment of hematologic malignancies and other cancers. The small molecule hCAR activator in combination with CPA based chemotherapy regimen provides a synergistic effect to help promote cytoxicity of the cyclophosphamide (CPA) based anticancer treatments including CHOP regimen (CPA, doxorubicin, vincristine, and prednisone) by preferential induction of CYP2B6 over CYP3A4 and promoting the formation of therapeutically active CPA metabolite 4-OH-CPA.
• US9605002B2
  申请人：——

  公开号：US9605002B2

  公开（公告）日：2017-03-28
• [EN] 5,5-HETEROAROMATIC ANTI-INFECTIVE COMPOUNDS<br/>[FR] COMPOSÉS ANTI-INFECTIEUX 5,5-HÉTÉROAROMATIQUES
  申请人：MORASKI GARRETT

  公开号：WO2014015167A2

  公开（公告）日：2014-01-23

  The invention provides a series of 5,5-heteroaromatic compounds, syntheses thereof, compositions thereof, and methods of using such compounds and compositions. Various embodiments provide methods of killing and/or inhibiting the growth of M. tuberculosis and/or M. avium, and methods of treating, preventing, and/or ameliorating M. tuberculosis and/or M. avium infections in a subject. In various embodiments, the 5,5-heteroaromatic compound is N-(4-(4-chlorophenoxy)benzyl)-2,6-dimethylimidazo[2,1-b]thiazole-5-carboxamide.