Benzyl 4-[[3-(4-cyclohexylphenyl)-2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]propanoyl]amino]benzoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Benzyl 4-[[3-(4-cyclohexylphenyl)-2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]propanoyl]amino]benzoate
• 英文别名: benzyl 4-[[3-(4-cyclohexylphenyl)-2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]propanoyl]amino]benzoate
• 化学式: C₃₆H₃₃F₅N₂O₅S
• 分子量: 700.7
• InChiKey: DCICAKHNVOVQML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  49
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• NEW SALICYLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF
  申请人：The Governing Council of the University of Toronto

  公开号：EP2854819A2

  公开（公告）日：2015-04-08
• [EN] NEW SALICYLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS D'ACIDE SALICYLIQUE, SEL DE QUALITÉ PHARMACEUTIQUE CORRESPONDANT, COMPOSITION ET PROCÉDÉ D'UTILISATION CORRESPONDANTS
  申请人：UNIV TORONTO

  公开号：WO2013177534A2

  公开（公告）日：2013-11-28

  The present invention relates to novel compounds, compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a STAT3 or STAT5-dependent cancer using said compounds; or a pharmaceutically acceptable salt, solvate or prodrug thereof.