2-[2-chloro-5-(trifluoromethyl)phenyl]-5-[4-(methylamino)pyrimidin-2-yl]-1H-pyrrole-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-[2-chloro-5-(trifluoromethyl)phenyl]-5-[4-(methylamino)pyrimidin-2-yl]-1H-pyrrole-3-carboxamide
• 化学式: C₁₇H₁₃ClF₃N₅O
• 分子量: 395.8
• InChiKey: PGKLPCMYVUVSQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  96.7
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS
  申请人：Nerviano Medical Sciences S.r.l.

  公开号：EP2880025A2

  公开（公告）日：2015-06-10
• [EN] SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS<br/>[FR] PYRROLES SUBSTITUÉS ACTIFS EN TANT QU'INHIBITEURS DE KINASE
  申请人：NERVIANO MEDICAL SCIENCES SRL

  公开号：WO2014019908A2

  公开（公告）日：2014-02-06

  The present invention relates to substituted pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.