16-(5-Amino-4-oxopentanoyl)oxyhexadecanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 16-(5-Amino-4-oxopentanoyl)oxyhexadecanoic acid
• 英文别名: 16-(5-amino-4-oxopentanoyl)oxyhexadecanoic acid
• 化学式: C₂₁H₃₉NO₅
• 分子量: 385.5
• InChiKey: XOTQBMBJCUTTTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  27
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] COMPOUNDS<br/>[FR] COMPOSÉS
  申请人：PHOTOCURE ASA

  公开号：WO2014020164A1

  公开（公告）日：2014-02-06

  The invention relates to new derivatives of 5-aminolevulinic acid (5-ALA) and their use as photosensitizing agents. In particular, it relates to compounds of general formula I and their pharmaceutically acceptable salts, to methods for preparing such compounds and their medical and cosmetic use, for example in methods of photodynamic therapy and diagnosis: wherein R1 represents a hydrogen atom or an optionally substituted alkyl or cycloalkyl group; R2, each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group; and X is a linking group.

  这项发明涉及5-氨基丙酮酸（5-ALA）的新衍生物及其用作光敏剂的用途。具体而言，涉及到一般式I的化合物及其药学上可接受的盐，以及制备这些化合物的方法及它们在医药和化妆品中的用途，例如在光动力疗法和诊断方法中：其中R1代表氢原子或可选择取代的烷基或环烷基基团；R2，每个可能相同或不同，代表氢原子或可选择取代的烷基基团；X是一个连接基。
• Compounds
  申请人：Photocure ASA

  公开号：US20150191419A1

  公开（公告）日：2015-07-09

  The invention relates to new derivatives of 5-aminolevulinic acid (5-ALA) and their use as photosensitizing agents. In particular, it relates to compounds of general formula I and their pharmaceutically acceptable salts, to methods for preparing such compounds and their medical and cosmetic use, for example in methods of photodynamic therapy and diagnosis: wherein R 1 represents a hydrogen atom or an optionally substituted alkyl or cycloalkyl group; R 2 , each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group; and X is a linking group.

  本发明涉及5-氨基戊酸（5-ALA）的新衍生物及其作为光敏剂的用途。特别地，涉及通式I的化合物及其药学上可接受的盐，用于制备此类化合物的方法以及它们在医学和美容上的应用，例如在光动力疗法和诊断方法中：其中R1代表氢原子或可选择取代的烷基或环烷基；R2，每个可能相同或不同，代表氢原子或可选择取代的烷基；而X是连接基。
• COMPOUNDS
  申请人：Photocure ASA

  公开号：EP2880012A1

  公开（公告）日：2015-06-10
• US9249086B2
  申请人：——

  公开号：US9249086B2

  公开（公告）日：2016-02-02