2-[Amino(hydroxy)methyl]-2-methylpentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[Amino(hydroxy)methyl]-2-methylpentanoic acid
• 英文别名: 2-[amino(hydroxy)methyl]-2-methylpentanoic acid
• 化学式: C₇H₁₅NO₃
• 分子量: 161.2
• InChiKey: BAUXRZWDHLCELH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  83.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• NEPRILYSIN INHIBITORS
  申请人：Theravance Biopharma R&D IP, LLC

  公开号：EP2882716A1

  公开（公告）日：2015-06-17
• [EN] NEPRILYSIN INHIBITORS<br/>[FR] INHIBITEURS DE NÉPRILYSINE
  申请人：THERAVANCE INC

  公开号：WO2014025891A1

  公开（公告）日：2014-02-13

  In one aspect, the invention relates to compounds having the formula (I): where X, Ra, Rb, R2, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.