2-hydroxy-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]benzamide | 1352238-69-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]benzamide
• CAS: 1352238-69-7
• 化学式: C₁₄H₆F₇NO₂
• 分子量: 353.196
• InChiKey: XWBLGSADNCJMLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 在 potassium peroxymonosulfate 作用下， 以 水 、 丙酮 为溶剂， 反应 2.0h， 以82%的产率得到2-hydroxy-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]benzamide
  参考文献：
  名称：

  Pd-Catalyzed Oxidative ortho-C–H Borylation of Arenes

  摘要：

  The development of a Pd-catalyzed oxidative ortho-C-H borylation with N-arylbenzamides is reported. A modified dibenzylideneacetone (dba) ligand, a weak base, and a strong oxidant are critical for obtaining good yields. The reaction is tolerant of electron-deficient and electron-rich benzamides derived from readily available benzoic acids. The borylated products can be converted to various synthons via diverse transformations.

  DOI：

  10.1021/ja2097095

文献信息

• Identification of monodentate oxazoline as a ligand for copper-promoted ortho-C–H hydroxylation and amination
  作者：Ming Shang、Qian Shao、Shang-Zheng Sun、Yan-Qiao Chen、Hui Xu、Hui-Xiong Dai、Jin-Quan Yu

  DOI：10.1039/c6sc03383k

  日期：——

  The use of a weakly coordinating monodentate directing group for copper mediated ortho-hydroxylation and amination reactions allows for the identification of an external oxazoline ligand as a promoter.

  使用弱配位单齿导向基团进行铜介导的邻位羟基化和胺化反应可以将外部恶唑啉配体鉴定为促进剂。
• Pd-Catalyzed Oxidative <i>ortho</i>-C–H Borylation of Arenes
  作者：Hui-Xiong Dai、Jin-Quan Yu

  DOI：10.1021/ja2097095

  日期：2012.1.11

  The development of a Pd-catalyzed oxidative ortho-C-H borylation with N-arylbenzamides is reported. A modified dibenzylideneacetone (dba) ligand, a weak base, and a strong oxidant are critical for obtaining good yields. The reaction is tolerant of electron-deficient and electron-rich benzamides derived from readily available benzoic acids. The borylated products can be converted to various synthons via diverse transformations.