2-[[2-Amino-2-(2-carboxyethoxymethyl)-3-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]propoxy]methyl]-3,3-dimethylbutanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[2-Amino-2-(2-carboxyethoxymethyl)-3-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]propoxy]methyl]-3,3-dimethylbutanoic acid
• 英文别名: 2-[[2-amino-2-(2-carboxyethoxymethyl)-3-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]propoxy]methyl]-3,3-dimethylbutanoic acid
• 化学式: C₂₁H₃₉NO₉
• 分子量: 449.5
• InChiKey: JKTBDMGREOLDOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  31
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  155
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• [EN] CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION<br/>[FR] AGENTS D'ARN CONJUGUÉS À DES GLUCIDES ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2014025805A1

  公开（公告）日：2014-02-13

  This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.

  这份披露涉及一种改进的碳水化合物结合物制备过程。该披露还涉及包含这些碳水化合物结合物的碳水化合物结合iRNA药剂，其具有改进的纯度，并且对于iRNA药剂的体内输送是有利的。
• CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20150196655A1

  公开（公告）日：2015-07-16

  This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.

  本公开涉及一种改进的糖类结合物制备工艺。本公开还涉及包含这些糖类结合物的糖类结合iRNA药剂，其具有改善的纯度，并且对于体内输送iRNA药剂是有优势的。
• Carbohydrate conjugated RNA agents and process for their preparation
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US10086081B2

  公开（公告）日：2018-10-02

  This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.

  本公开涉及一种用于制备碳水化合物共轭物的改进工艺。本公开还涉及由这些碳水化合物共轭物组成的碳水化合物共轭 iRNA 制剂，这些制剂的纯度有所提高，有利于 iRNA 制剂的体内递送。