Phenol;2-phenoxyethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Phenol;2-phenoxyethanol
• 英文别名: phenol;2-phenoxyethanol
• 化学式: C14H16O3
• 分子量: 232.27
• InChiKey: HHBMLRNXOCVGFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.45
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] BIOADHESIVE FORMULATIONS FOR USE IN DRUG DELIVERY<br/>[FR] FORMULATIONS BIOADHÉSIVES DESTINÉES À ÊTRE UTILISÉES DANS L'ADMINISTRATION DE MÉDICAMENTS
  申请人：EDKO PAZARLAMA TANITIM TICARET LTD SIRKETI

  公开号：WO2014027006A1

  公开（公告）日：2014-02-20

  This invention relates to formulations having bioadhesive properties for use in drug delivery, in particular for the delivery of a drug or combination of drugs to body cavities and/or body surfaces. These are particularly suitable for the delivery of drugs to mucosal surfaces, in particular to vaginal mucosa.
• [EN] ANTI-VAGINITIS COMPOSITIONS WITH IMPROVED RELEASE AND ADHERENCE<br/>[FR] COMPOSITIONS ANTI-VAGINITE À LIBÉRATION ET ADHÉRENCE AMÉLIORÉES
  申请人：EDKO PAZARLAMA TANITIM TICARET LTD SIRKETI

  公开号：WO2014026707A1

  公开（公告）日：2014-02-20

  The present invention relates to a pharmaceutical composition for treatment of vaginitis comprising: at least one active agent effective against Candida spp., Trichomonas vaginalis and/or Gardnerella vaginalis in an extended release form; a poloxamer mixture containing at least two poloxamers; a fatty acid ester derived from a C8 to C22 saturated or unsaturated fatty acid; and a glycol ether. The novel composition herein described is highly bioadhesive with improved retention time specifically in vaginal conditions.