H-Phe-Ser(CHF2)-Leu-Unk

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Phe-Ser(CHF2)-Leu-Unk
• 英文别名: (2S)-2-amino-N-[(2S)-3-(difluoromethoxy)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-3-phenylpropanamide
• 化学式: C₂₂H₃₁F₂N₃O₅
• 分子量: 455.5
• InChiKey: YWSWWZZHEAXYJX-ACTFIFLWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  32
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  123
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• FLUORINATED EPOXYKETONE-BASED COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS
  申请人：FLUORINOV PHARMA INC.

  公开号：US20150203534A1

  公开（公告）日：2015-07-23

  The present application relates to novel fluorinated epoxyketone-based compounds, compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions mediated by proteasome inhibition, in particular, the present application includes compounds of Formula I, and compositions and uses thereof:

  本申请涉及新型氟代环氧酮基化合物，包括这些化合物的组合物和它们的用途，特别是用于治疗由蛋白酶体抑制介导的疾病、紊乱或病况，特别是本申请包括公式I的化合物，以及它们的组合物和用途：
• US9441012B2
  申请人：——

  公开号：US9441012B2

  公开（公告）日：2016-09-13
• [EN] FLUORINATED EPOXYKETONE-BASED COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS<br/>[FR] COMPOSÉS À BASE D'ÉPOXYCÉTONE FLUORÉS ET LEURS UTILISATIONS EN TANT QU'INHIBITEURS DU PROTÉASOME
  申请人：SLASSI ABDELMALIK

  公开号：WO2014026282A1

  公开（公告）日：2014-02-20

  The present application relates to novel fiuorinated epoxyketone-based compounds, compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions mediated by proteasome inhibition, in particular, the present application includes compounds of Formula I, and compositions and uses thereof: