2-[2-(2-Aminoethyl)cyclobutyl]acetic acid;octanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-[2-(2-Aminoethyl)cyclobutyl]acetic acid;octanoic acid
• 英文别名: 2-[2-(2-aminoethyl)cyclobutyl]acetic acid;octanoic acid
• 化学式: C16H31NO4
• 分子量: 301.42
• InChiKey: GSAYFBDTRADMRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.27
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Cyclopentane-peptide nucleic acids for qualitative and quantitative detection of nucleic acids
  申请人：THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES

  公开号：US10457978B2

  公开（公告）日：2019-10-29

  The invention concerns methods for detecting a nucleic acid of interest in a solution comprising (a) contacting a solution suspected of containing the nucleic acid of interest with a PNA capture probe and a PNA reporter probe; wherein (i) the PNA capture probe comprises at least two trans-cyclopentanes; (ii) the PNA reporter probe comprises at least six biotin groups; (iii) the PNA capture probe bound to a surface; and (iv) the PNA capture probe and the PNA reporter probe each comprise a nucleobase sequence that is complementary to different non-overlapping portions of the nucleic acid of interest; (b) detecting the presence of the PNA capture probe and the PNA reporter probe bound to the surface; wherein the nucleic acid of interest is detected when 1-1000 molecules of the nucleic acid of interest are present in the solution being tested.

  本发明涉及检测溶液中感兴趣的核酸的方法，包括(a)将怀疑含有感兴趣的核酸的溶液与PNA捕获探针和PNA报告探针接触；其中(i)PNA捕获探针包括至少两个反式环戊烷；(ii)PNA报告探针包括至少六个生物素基团；(iii)PNA捕获探针结合到表面；(iv) PNA 捕获探针和 PNA 报告探针各自包括与所要检测的核酸的不同非重叠部分互补的核碱基序列； (b) 检测与表面结合的 PNA 捕获探针和 PNA 报告探针的存在；其中，当被测溶液中存在 1-1000 个分子的所要检测的核酸时，检测所要检测的核酸。
• CYCLOPENTANE-PEPTIDE NUCLEIC ACIDS FOR QUALITATIVE AND QUANTITATIVE DETECTION OF NUCLEIC ACIDS
  申请人：The United States of America, as Represented by The Secretary, Department of Health and Human Services

  公开号：EP2885424B1

  公开（公告）日：2016-10-05
• [EN] CYCLOPENTANE-PEPTIDE NUCLEIC ACIDS FOR QUALITATIVE AND QUANTITATIVE DETECTION OF NUCLEIC ACIDS<br/>[FR] CYCLOPENTANE-ACIDES NUCLÉIQUES PEPTIDIQUES POUR LA DÉTECTION QUALITATIVE ET QUANTITATIVE D'ACIDES NUCLÉIQUES
  申请人：US HEALTH

  公开号：WO2014028793A1

  公开（公告）日：2014-02-20

  The invention concerns methods for detecting a nucleic acid of interest in a solution comprising (a) contacting a solution suspected of containing the nucleic acid of interest with a PNA capture probe and a PNA reporter probe; wherein (i) the PNA capture probe comprises at least two trans-cyclopentanes; (ii) the PNA reporter probe comprises at least six biotin groups; (iii) the PNA capture probe bound to a surface; and (iv) the PNA capture probe and the PNA reporter probe each comprise a nucleobase sequence that is complementary to different non- overlapping portions of the nucleic acid of interest; (b) detecting the presence of the PNA capture probe and the PNA reporter probe bound to the surface; wherein the nucleic acid of interest is detected when 1-1000 molecules of the nucleic acid of interest are present in the solution being tested.