1-Pyridin-2-yloxy-1-(2,4,6-trimethylphenoxy)propan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-Pyridin-2-yloxy-1-(2,4,6-trimethylphenoxy)propan-2-ol
• 英文别名: 1-pyridin-2-yloxy-1-(2,4,6-trimethylphenoxy)propan-2-ol
• 化学式: C₁₇H₂₁NO₃
• 分子量: 287.35
• InChiKey: PGUHDUKSVXMYIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  51.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PRO-NEUROGENIC COMPOUNDS
  申请人：Board of Regents of the University of Texas System

  公开号：EP2925129A1

  公开（公告）日：2015-10-07
• [EN] PRO-NEUROGENIC COMPOUNDS<br/>[FR] COMPOSÉS PRO-NEUROGÈNES
  申请人：UNIV TEXAS

  公开号：WO2014031125A1

  公开（公告）日：2014-02-27

  This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.