申请人:——
公开号:US20020076443A1
公开(公告)日:2002-06-20
The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic agent. The matrix may comprise one or more phases in addition to an aqueous phase, such as a solid and/or oil phase. The matrix of the invention has at least one controlled release in-vivo kinetic profile, and may have additional profiles for the same agent. The matrix may also comprise more than one therapeutic agent, and each additional therapeutic agent may have one or more controlled release in-vivo kinetic profile.
本发明涉及制备药物组合物和制备药物组合物的方法,其中药物组合物包括至少一种治疗剂物理上被包裹在交联基质中。该基质可能包括除水相外的一个或多个相,例如固体和/或油相。本发明的基质具有至少一个体内控制释放动力学特性,并且可能具有相同药物的其他特性。基质还可以包括多种治疗剂,每种附加治疗剂可能具有一个或多个体内控制释放动力学特性。