The present application relates to novel fluorinated epoxyketone-based tetrapeptide compounds, compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions mediated by proteasome inhibition. In particular, the present application includes compounds of Formula I, and compositions and uses thereof:
本申请涉及一种新颖的含
氟环
氧酮基四肽化合物,包含这些化合物的组合物及其用途,特别是用于治疗由
蛋白酶体抑制介导的疾病、紊乱或状况。特别是,本申请包括公式I的化合物,以及其组合物和用途: