(E)-2-methyl-1-morpholin-4-ylhex-4-en-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (E)-2-methyl-1-morpholin-4-ylhex-4-en-1-one
• 化学式: C₁₁H₁₉NO₂
• 分子量: 197.27
• InChiKey: HHAGIMUOFHFSLC-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] METHODS OF USE FOR MONOMETHYL FUMARATE AND PRODRUGS THEREOF<br/>[FR] PROCÉDÉS D'UTILISATION DE FUMARATE DE MONOMÉTHYLE ET PROMÉDICAMENTS CORRESPONDANTS
  申请人：XENOPORT INC

  公开号：WO2014031901A1

  公开（公告）日：2014-02-27

  Methods of treating a disease in a patient comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound selected from: (i) monomethyl fumarate, (ii) a prodrug of monomethyl fumarate, and (iii) combinations thereof, wherein the disease is chosen from balo concentric sclerosis, bronchiolitis obliterans organizing pneumonia, central nervous system vasculitis, Charcott- Marie-Tooth Disease, childhood ataxia with central nervous system hypomyelination, diabetic retinopathy, graft versus host disease, monomelic amyotrophy, neurodegeneration with brain iron accumulation, neurosarcoidosis, pareneoplastic syndromes, subacute necrotizing myelopathy, Susac syndrome and transverse myelitis.