(2S)-2-[[(2S)-3-(difluoromethoxy)-2-[[(2S)-3-(difluoromethoxy)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanoyl]amino]-N-[(2S)-4-methyl-1-[(2S)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]-3-phenylpropanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-[[(2S)-3-(difluoromethoxy)-2-[[(2S)-3-(difluoromethoxy)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanoyl]amino]-N-[(2S)-4-methyl-1-[(2S)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]-3-phenylpropanamide
• 化学式: C₃₂H₄₅F₄N₅O₉
• 分子量: 719.7
• InChiKey: LXGPYCWUGLARKJ-DMXMQRLASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  50
• 可旋转键数：
  21
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  177
• 氢给体数：
  4
• 氢受体数：
  14

文献信息

• FLUORINATED EPOXYKETONE-BASED TETRAPEPTIDE COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS
  申请人：FLUORINOV PHARMA INC.

  公开号：US20150218212A1

  公开（公告）日：2015-08-06

  The present application relates to novel fluorinated epoxyketone-based tetrapeptide compounds, compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions mediated by proteasome inhibition. In particular, the present application includes compounds of Formula I, and compositions and uses thereof:

  本申请涉及一种新颖的含氟环氧酮基四肽化合物，包含这些化合物的组合物及其用途，特别是用于治疗由蛋白酶体抑制介导的疾病、紊乱或状况。特别是，本申请包括公式I的化合物，以及其组合物和用途：
• [EN] FLUORINATED EPOXYKETONE-BASED TETRAPEPTIDE COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS<br/>[FR] COMPOSÉS TÉTRAPEPTIDIQUES À BASE D'ÉPOXYCÉTONE FLUORÉE ET LEURS UTILISATIONS EN TANT QU'INHIBITEUR DU PROTÉASOME
  申请人：SLASSI ABDELMALIK

  公开号：WO2014029022A1

  公开（公告）日：2014-02-27

  The present application relates to novel fluorinated epoxyketone-based tetrapeptide compounds, compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions mediated by proteasome inhibition. In particular, the present application includes compounds of Formula I, and compositions and uses thereof: