Cambridge id 5323894

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Cambridge id 5323894
• 英文别名: 1-[4-(3-methylphenoxy)butyl]piperidine
• 化学式: C₁₆H₂₅NO
• 分子量: 247.38
• InChiKey: LQPLLVVUKAYHDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• 1,3,5-Trisubstituted 2(1H)-pyridones as AMPA receptor inhibitors useful for the treatment of eg Parkinson's disease
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2053041A2

  公开（公告）日：2009-04-29

  The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6alkyl group or a group represented by the formula -X-A (wherein X indicates a single bond, an optionally sbutituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

  本发明提供了一种新的化合物，具有出色的AMPA受体抑制作用和/或kainate抑制作用。该化合物由以下公式所表示，其盐或水合物。在公式中，Q表示NH，O或S; R1、R2、R3、R4和R5相同或不同，每个表示氢原子、卤原子、C1-6烷基或由公式-X-A表示的基团（其中X表示单键、可选择的取代C1-6烷基等; A表示可选择的取代C6-14芳香族烃环基或5-至14环芳香族杂环基等）。
• 1,2-DIHYDROPYRIDINE COMPOUNDS, MANUFACTURING METHOD THEREOF AND USE THEREOF
  申请人：NAGATO Satoshi

  公开号：US20090275751A1

  公开（公告）日：2009-11-05

  The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R 1 , R 2 , R 3 , R 4 and R 5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C 1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C 1-6 alkylene group etc.; and A indicates an optionally substituted C 6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

  本发明提供了一种新型化合物，具有优异的AMPA受体抑制作用和/或kainate抑制作用。该化合物的化学式如下，其盐或水合物：在该式中，Q表示NH、O或S；R1、R2、R3、R4和R5相同或不同，且每个表示氢原子、卤素原子、C1-6烷基或由式—X-A表示的基团（其中X表示单键、可选地取代的C1-6烷基等；A表示可选地取代的C6-14芳香烃环基或5-至14元杂环芳香族基等）。
• 1,2-DIHYDROPYRIDINE COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1300396B1

  公开（公告）日：2009-01-14
• PHARMACEUTICAL COMPOSITIONS (KIT) COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY (OR AN ANTIINFLAMMATORY) AGENT AND THEIR USES
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1465626B1

  公开（公告）日：2008-09-03
• US7563811B2
  申请人：——

  公开号：US7563811B2

  公开（公告）日：2009-07-21