4-[3-(2-chlorophenoxy)propyl]-3,5-dimethyl-1H-pyrazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-[3-(2-chlorophenoxy)propyl]-3,5-dimethyl-1H-pyrazole
• 化学式: C₁₄H₁₇ClN₂O
• 分子量: 264.75
• InChiKey: UWFOWUWGOVNWPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Systems for stabilizing and delivering active agents
  申请人：Alhamadsheh Mamoun M

  公开号：US10172959B2

  公开（公告）日：2019-01-08

  A delivery system for active agents, and methods of making and using the systems, are provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

  本文提供了一种用于活性剂的递送系统，以及制造和使用该系统的方法。这些给药系统具有：(i) 对受试者血清中的内源性血浆蛋白具有选择性的配体；(ii) 用于将配体共价连接到活性剂上以延长活性剂在血清中的半衰期的连接体。
• Enhanced active agents
  申请人：Alhamadsheh Mamoun M

  公开号：US10363318B2

  公开（公告）日：2019-07-30

  The teachings provide active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Methods of making and using the systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

  本教导提供了与递送系统共轭的活性制剂，可延长活性制剂的半衰期并降低其免疫原性。还提供了制造和使用这些系统的方法。这些递送系统具有：(i) 对受试者血清中的内源性血浆蛋白具有选择性的配体；(ii) 连接体，用于将配体共价连接到活性剂上，以延长活性剂在血清中的半衰期。
• Delivering enhanced active agents
  申请人：Alhamadsheh Mamoun M

  公开号：US10596269B2

  公开（公告）日：2020-03-24

  The teachings provide methods of delivering active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Delivery systems and methods of making and using the delivery systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

  本教导提供了输送活性剂的方法，这些活性剂与输送系统共轭，可延长活性剂的半衰期并降低免疫原性。还提供了递送系统以及制造和使用递送系统的方法。这些给药系统具有：(i) 对受试者血清中的内源性血浆蛋白具有选择性的配体；(ii) 用于将配体共价连接到活性剂上以延长活性剂在血清中的半衰期的连接体。
• Enhanced anticancer agent
  申请人：Alhamadsheh Mamoun M

  公开号：US10772967B2

  公开（公告）日：2020-09-15

  The teachings provide methods of delivering active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Delivery systems and methods of making and using the delivery systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

  本教导提供了输送活性剂的方法，这些活性剂与输送系统共轭，可延长活性剂的半衰期并降低免疫原性。还提供了递送系统以及制造和使用递送系统的方法。这些给药系统具有：(i) 对受试者血清中的内源性血浆蛋白具有选择性的配体；(ii) 用于将配体共价连接到活性剂上以延长活性剂在血清中的半衰期的连接体。
• Enhanced SN-38 anticancer agent
  申请人：Alhamadsheh Mamoun M

  公开号：US11129902B2

  公开（公告）日：2021-09-28

  The teachings provide methods of delivering active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Delivery systems and methods of making and using the delivery systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

  本教导提供了输送活性剂的方法，这些活性剂与输送系统共轭，可延长活性剂的半衰期并降低免疫原性。还提供了递送系统以及制造和使用递送系统的方法。这些给药系统具有：(i) 对受试者血清中的内源性血浆蛋白具有选择性的配体；(ii) 用于将配体共价连接到活性剂上以延长活性剂在血清中的半衰期的连接体。