4-(1-Hydroxyethylamino)-4-oxobutanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-(1-Hydroxyethylamino)-4-oxobutanoic acid
• 英文别名: 4-(1-hydroxyethylamino)-4-oxobutanoic acid
• 化学式: C₆H₁₁NO₄
• 分子量: 161.16
• InChiKey: FRKNBUQOJLUGKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• THICKENING COMPOSITION CONTAINING LIPID PEPTIDE-TYPE COMPOUND
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP3143982A1

  公开（公告）日：2017-03-22

  There is provided a thickened composition that does not lose viscosity even in the presence of an organic acid such as ascorbic acid or a salt thereof. A thickened composition, comprising a polyhydric alcohol, water, an organic acid, and a lipid peptide-type compound containing at least one of a compound of Formula (1) to Formula (3) below and a pharmaceutically usable salt of the compound of Formula (1) to Formula (3), where R1 is a C9-23 aliphatic group, R2 is a hydrogen atom or a C1-4 alkyl group that optionally has a C1-2 branched chain, R3 is a -(CH2) n-X group, n is a number of 1 to 4, X is an amino group, a guanidino group, a -CONH2 group, a 5-membered ring group optionally containing 1 to 3 nitrogen atom(s), a 6-membered ring group optionally containing 1 to 3 nitrogen atom(s), or a condensed heterocycle group that contains a 5-membered ring and a 6-membered ring optionally containing 1 to 3 nitrogen atom(s).

  本发明提供了一种即使在有机酸如抗坏血酸或其盐存在的情况下也不会失去粘度的增稠组合物。一种增稠组合物，由多元醇、水、有机酸和脂质肽类化合物组成，该化合物含有下式（1）至式（3）化合物中的至少一种，以及式（1）至式（3）化合物的药用盐、 其中 R1 是 C9-23 脂肪族基团，R2 是氢原子或任选具有 C1-2 支链的 C1-4 烷基，R3 是-(CH2) n-X 基团，n 是 1 至 4 的数字，X 是氨基、胍基、-CONH2 基团、可选含有 1 至 3 个氮原子的 5 元环基团、可选含有 1 至 3 个氮原子的 6 元环基团、或含有 1 至 3 个氮原子的 5 元环和 6 元环的缩合杂环基团。
• POLYURETHANE POLYUREA, METHOD FOR PRODUCING SAME AND COSMETIC COMPOSITION CONTAINING SAME
  申请人：Adeka Corporation

  公开号：EP3225643A1

  公开（公告）日：2017-10-04

  It is an object of the present invention to provide an additive having strong thickening and gelling effects, the additive being capable of thickening and gelling silicone oils and ester oils even when added in a small amount. To achieve this object, the present invention provides, as the additive, a polyurethane polyurea obtained by reacting a polyurethane polyurea prepolymer obtained from a silicone derivative starting material having a specific structure, a specific diisocyanate compound starting material and a starting material made up of a compound represented by General Formula (C) below (each of which is set forth in the Description), with either or both of a nitrogen compound having a specific structure and a hydroxyl group-containing compound having a specific structure (each of which is set forth in the Description): where R30 represents a C1-10 divalent hydrocarbon group or oxygen atom, and y represents a number 0 or 1; however, when R30 is a C1-10 divalent hydrocarbon group, y represents the number 1, and when R30 is an oxygen atom, y represents the number 0.

  本发明的目的是提供一种添加剂，该添加剂具有很强的增稠和胶凝效果，即使添加量很小，也能使硅油和酯油增稠和胶凝。 为实现这一目的，本发明提供了一种聚氨酯聚脲作为添加剂，该添加剂是由具有特定结 构的有机硅衍生物起始原料、特定的二异氰酸酯化合物起始原料和由下式（C）所代表的化合物 组成的起始原料（其中每种化合物均在描述中列出）与具有特定结构的含氮化合物和具有特定结 构的含羟基化合物（其中每种化合物均在描述中列出）中的一种或两种进行反应而得到的聚氨酯 聚脲预聚物： 其中 R30 代表 C1-10 二价烃基或氧原子，y 代表数字 0 或 1；然而，当 R30 为 C1-10 二价烃基时，y 代表数字 1，当 R30 为氧原子时，y 代表数字 0。
• POWDER-CONTAINING COMPOSITION, POWDER FOR AQUEOUS SOLVENT, AND PRODUCTION METHOD OF POWDER FOR AQUEOUS SOLVENT
  申请人：Shiseido Company, Ltd.

  公开号：EP3750960A1

  公开（公告）日：2020-12-16

  A powder-containing composition contains an aqueous solvent, a cationic polymer that is present in the aqueous solvent and a powder that bears a negative charge on a surface in the aqueous solvent and has a BET specific surface area of less than 50 m2/g. A ratio of the mass in the composition of the cationic polymer to a total surface area in the composition of the powder is 1 µg/m2 to 100,000 µg/m2.

  一种含粉末的组合物含有一种水性溶剂、一种存在于水性溶剂中的阳离子聚合物和一种粉末，该粉末在水性溶剂中的表面带有负电荷，其 BET 比表面积小于 50 m2/g。阳离子聚合物在组合物中的质量与粉末在组合物中的总表面积之比为 1 µg/m2 至 100,000 µg/m2。
• SKIN COLOR-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN COLOR
  申请人：Showa Denko K.K.

  公开号：EP3185850B1

  公开（公告）日：2019-10-09
• [EN] SILK LYOGELS FOR SUSTAINED RELEASE OF PROTEIN THERAPEUTICS AND METHODS OF MAKING AND USES<br/>[FR] LYOGELS DE SOIE POUR LA LIBÉRATION PROLONGÉE DE PRODUITS THÉRAPEUTIQUES PROTÉIQUES ET PROCÉDÉS DE FABRICATION ET D'UTILISATION ASSOCIÉS
  申请人：SANOFI SA

  公开号：WO2014035798A1

  公开（公告）日：2014-03-06

  The present disclosure provides silk lyogels made with a hydrophobicity, ionic, or stability modification for use in sustained release of antibodies and other protein therapeutics. The disclosure also provides methods of making silk lyogels.