20-[[(1S)-1-carboxy-4-[2-(2-hydroxyethoxy)ethylamino]-4-oxobutyl]amino]-20-oxoicosanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 20-[[(1S)-1-carboxy-4-[2-(2-hydroxyethoxy)ethylamino]-4-oxobutyl]amino]-20-oxoicosanoic acid
• 化学式: C₂₉H₅₄N₂O₈
• 分子量: 558.7
• InChiKey: KLPPAQOWKNGCQA-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  39
• 可旋转键数：
  29
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  162
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Insulin analogues with an acyl and alkylene glycol moiety
  申请人：NOVO NORDISK A/S

  公开号：EP2708554A1

  公开（公告）日：2014-03-19

  An acylated insulin analogue wherein the insulin analogue comprises a lysine residue connected C-terminally to the A21 amino acid residue or a peptide residue of up to 4 amino acid residues comprising a lysine residue which peptide residue is connected C-terminally to the A21 amino acid residue, characterized in that an acyl moiety comprising an alkylene glycol moiety is attached to the lysine residue in the A22 position or attached to a lysine residue present in the peptide residue that is attached to the C terminal end of the A21 amino acid residue and wherein there is only one lysine (K, Lys) in the insulin analogue, can conveniently be administered pulmonary.

  一种酰化的胰岛素类似物，其中胰岛素类似物包括一个 C 端连接到 A21 氨基酸残基的赖氨酸残基或一个最多 4 个氨基酸残基的肽残基，该肽残基包括一个 C 端连接到 A21 氨基酸残基的赖氨酸残基、其特征在于，由亚烷基二醇分子组成的酰基连接到 A22 位置的赖氨酸残基上，或连接到肽残基中存在的赖氨酸残基上，该肽残基连接到 A21 氨基酸残基的 C 端，并且胰岛素类似物中只有一个赖氨酸（K，Lys），可以方便地进行肺部给药。
• INSULIN ANALOGUES WITH AN ACYL AND AKLYLENE GLYCOL MOIETY
  申请人：Novo Nordisk A/S

  公开号：EP2178912B1

  公开（公告）日：2015-07-08
• [EN] PHARMACEUTICAL COMPOSITION FOR ORAL INSULIN ADMINISTRATION COMPRISING A TABLET CORE AND A POLYVINYL ALCOHOL COATING<br/>[FR] COMPOSITION PHARMACEUTIQUE POUR L'ADMINISTRATION D'INSULINE PAR VOIE ORALE COMPRENANT UN NOYAU DE COMPRIMÉ ET UN ENROBAGE D'ALCOOL POLYVINYLIQUE
  申请人：NOVO NORDISK AS

  公开号：WO2016119854A1

  公开（公告）日：2016-08-04

  The present invention relates to a solid oral insulin composition comprising a salt of capric acid which enhances the bioavailability and/or the absorption of said acylated insulin in combination with a polyvinyl alcohol coating, which is soluble in aqueous media independent of pH.