2-[2-[2,3-Bis(2-hydroxyethoxy)cyclopentyl]-2-(2-hydroxyethoxy)ethoxy]ethyl tridecanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-[2-[2,3-Bis(2-hydroxyethoxy)cyclopentyl]-2-(2-hydroxyethoxy)ethoxy]ethyl tridecanoate
• 英文别名: 2-[2-[2,3-bis(2-hydroxyethoxy)cyclopentyl]-2-(2-hydroxyethoxy)ethoxy]ethyl tridecanoate
• 化学式: C₂₈H₅₄O₉
• 分子量: 534.7
• InChiKey: WFLQDZJQQVZVNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  37
• 可旋转键数：
  27
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Sensory-Specific Local Anesthesia and Prolonged Duration Local Anesthesia
  申请人：Massachusetts Institute of Technology

  公开号：US20140080913A1

  公开（公告）日：2014-03-20

  Combinations of charged local anesthetics with chemical permeation enhancers have been developed to give long duration block which is selective for sensory block is greatly prolonged by combining the local anesthetic with a permeation enhancer. The selectivity of sensory over motor block is provided by selecting the concentration of the local anesthetic and the permeation enhancer to provide selective permeability of the sensory and motor neurons to the enhancer.