1-O-[2-(dimethylamino)ethyl] 5-O-ethyl 2-chloro-4-methylpentanedioate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-O-[2-(dimethylamino)ethyl] 5-O-ethyl 2-chloro-4-methylpentanedioate
• 化学式: C₁₂H₂₂ClNO₄
• 分子量: 279.76
• InChiKey: KCGKXZQGNALQKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] POLYMERS FOR SIRNA DELIVERY<br/>[FR] POLYMÈRES POUR LA LIBÉRATION D'ARNSI
  申请人：UNIV QUEENSLAND

  公开号：WO2014015367A1

  公开（公告）日：2014-01-30

  The present invention relates to a polymer delivery system for RNAi therapies that includes diseases where siRNA may be effective. In particular the invention relates to polymeric structures that self assemble into nano particles for siRNA delivery. Such polymers include a block copolymer comprising a cationic polymer capable of binding to siRNA, a p H mediator capable of disrupting endosomes and a polymer capable of binding with cell membrane thereby to release the block copolymer into the cytoplasm and wherein the cationic polymer is capable of degradation thereby to deliver siRNA.