2-(dodecylcarbamoylamino)-3-hydroxy-N-[(3E,5S,8S,9E)-5-methyl-2,7-dioxo-1,6-diazacyclododeca-3,9-dien-8-yl]propanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(dodecylcarbamoylamino)-3-hydroxy-N-[(3E,5S,8S,9E)-5-methyl-2,7-dioxo-1,6-diazacyclododeca-3,9-dien-8-yl]propanamide
• 化学式: C₂₇H₄₇N₅O₅
• 分子量: 521.7
• InChiKey: DGSGEHKOXCAFME-XJQMLLJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  37
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  149
• 氢给体数：
  6
• 氢受体数：
  5

文献信息

• Syringolin and glidobactin analogs as proteasome inhibitors for the treatment of cancer
  申请人：The Regents of the University of California

  公开号：EP2861565B1

  公开（公告）日：2016-12-21
• SUBSTITUTED MACROCYCLIC COMPOUNDS HAVING PROTEASOME INHIBITORY ACTIVITY
  申请人：THE GEGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150141392A1

  公开（公告）日：2015-05-21

  The disclosure provides for novel compounds which have proteasome inhibitory activity, pharmaceutical compositions made thereof, and methods of use thereof to treat various disorders, including cancer and nonmalignant tumors.
• US9399627B2
  申请人：——

  公开号：US9399627B2

  公开（公告）日：2016-07-26
• [EN] SUBSTITUTED MACROCYCLIC COMPOUNDS HAVING PROTEASOME INHIBITORY ACTIVITY<br/>[FR] COMPOSÉS MACROCYCLIQUES SUBSTITUÉS À ACTIVITÉ D'INHIBITION DES PROTÉASOMES
  申请人：UNIV CALIFORNIA

  公开号：WO2013188750A2

  公开（公告）日：2013-12-19

  The disclosure provides for novel compounds which have proteasome inhibitory activity, pharmaceutical compositions made thereof, and methods of use thereof to treat various disorders, including cancer and nonmalignant tumors.