P,P-diphenyl-P-(2-phenylethyl)(N-methoxycabonyl)phosphazene | 347192-80-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: P,P-diphenyl-P-(2-phenylethyl)(N-methoxycabonyl)phosphazene
• 英文别名: methyl N-[diphenyl(2-phenylethyl)-lambda5-phosphanylidene]carbamate；methyl N-[diphenyl(2-phenylethyl)-λ5-phosphanylidene]carbamate
• CAS: 347192-80-7
• 化学式: C₂₂H₂₂NO₂P
• 分子量: 363.396
• InChiKey: FPBRKDJHLQRNNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  P,P-diphenyl-P-(2-phenylethyl)(N-methoxycabonyl)phosphazene 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  通过磷腈进行烯烃化反应

  摘要：

  报道了通过对二苯基（烷基）（N-羧甲基）磷腈锂与醛和酮的反应首次合成二、三和四取代烯烃。

  DOI：

  10.1039/b006413k
• 作为产物：
  描述：

  苯乙基二苯基膦 、 叠氮基甲酸甲酯 以 四氢呋喃 为溶剂， 生成 P,P-diphenyl-P-(2-phenylethyl)(N-methoxycabonyl)phosphazene
  参考文献：
  名称：

  Reactions of lithiated P -diphenyl(alkyl)( N -methoxycarbonyl)phosphazenes with Michael acceptors and aldehydes. Synthesis of 1 H -1,2-azaphosphinin-6-ones, β-hydroxy( N -methoxycarbonyl)phosphazenes and 5,6-dihydro-1,3,4-oxazaphosphinin-2-ones

  摘要：

  Lithium (N-methoxycarbonyl)phosphazenes add C-regioselectively to DMAD, dimethyl malonate, fumarate, and butyl idenmalonate in a [1,4] manner. Only one diastereoisomer is observed with the olefinic electrophiles. With DMAD the initial adduct evolves through cyclocondensation with the CO2Me group of the phosphazene and 1H-1,2-azaphosphinin-6-ones are obtained. Exceptionally, methyl phenylpropiolate reacted exclusively through the carbonyl yielding a mixture of C- and N-acylated compounds. The addition to aldehydes at -80 degreesC affords beta -hydroxyphosphazenes diastereoselectively. For lithium oc,bi-dimethyl(N-methoxycarbonyl)phospha the intermediate all;oxides cyclocondense at room temperature to 5,6-dihydro-1,3,4-oxazaphosphinin-2-ones. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00165-x

文献信息

• Synthesis of 1H-1,2 λ5-Azaphosphinin-6-ones from N-alkoxycarbonyl phosphazenes and DMAD
  作者：Julia M. Álvarez-Gutiérrez、Fernando López-Ortiz

  DOI：10.1016/0040-4039(96)00401-7

  日期：1996.4

  1H-1,2λ5-Azaphosphinin-6-ones are prepared by reaction of DMAD with metallated N-alkoxycarbonyl alkyldiphenylphosphazenes.

  1H-1,2 λ 5 -Azaphosphinin -6-酮通过用金属化DMAD的反应制备ñ -烷氧基羰alkyldiphenylphosphazenes。
• Reactions of lithiated P -diphenyl(alkyl)( N -methoxycarbonyl)phosphazenes with Michael acceptors and aldehydes. Synthesis of 1 H -1,2-azaphosphinin-6-ones, β-hydroxy( N -methoxycarbonyl)phosphazenes and 5,6-dihydro-1,3,4-oxazaphosphinin-2-ones
  作者：Julia M Álvarez-Gutiérrez、Emma Peralta-Pérez、Isidro Pérez-Álvarez、Fernando López-Ortiz

  DOI：10.1016/s0040-4020(01)00165-x

  日期：2001.4

  Lithium (N-methoxycarbonyl)phosphazenes add C-regioselectively to DMAD, dimethyl malonate, fumarate, and butyl idenmalonate in a [1,4] manner. Only one diastereoisomer is observed with the olefinic electrophiles. With DMAD the initial adduct evolves through cyclocondensation with the CO2Me group of the phosphazene and 1H-1,2-azaphosphinin-6-ones are obtained. Exceptionally, methyl phenylpropiolate reacted exclusively through the carbonyl yielding a mixture of C- and N-acylated compounds. The addition to aldehydes at -80 degreesC affords beta -hydroxyphosphazenes diastereoselectively. For lithium oc,bi-dimethyl(N-methoxycarbonyl)phospha the intermediate all;oxides cyclocondense at room temperature to 5,6-dihydro-1,3,4-oxazaphosphinin-2-ones. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Olefination reactions through phosphazenes
  作者：Emma Peralta Pérez、Fernando López Ortiz

  DOI：10.1039/b006413k

  日期：——

  The first synthesis of di-, tri- and tetrasubstituted alkenes through reaction of lithium P-diphenyl(alkyl)(N-carboxymethyl)phosphazenes with aldehydes and ketones is reported.

  报道了通过对二苯基（烷基）（N-羧甲基）磷腈锂与醛和酮的反应首次合成二、三和四取代烯烃。