2-[(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoyl]oxyethyl 2,5-bis(ethenyl)oxolane-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-[(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoyl]oxyethyl 2,5-bis(ethenyl)oxolane-3-carboxylate
• 化学式: C₄₄H₄₉FN₂O₈
• 分子量: 752.9
• InChiKey: JLJUZVBFQMWYRK-FPABQPNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  55
• 可旋转键数：
  20
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• HIGHLY ACTIVE METATHESIS CATALYSTS SELECTIVE FOR ROMP AND RCM REACTIONS
  申请人：ZHAN Zheng-Yun James

  公开号：US20140080984A1

  公开（公告）日：2014-03-20

  The present invention relates to a kind of novel carbene ligands and ruthenium catalysts, which is highly active and selective for ROMP and RCM reactions, respectively. It discloses the significant electronic and steric effect of different substituted carbene ligands on the catalytic activity and stability of corresponding carbene ruthenium complexes; some of novel ruthenium complexes in the invention can be broadly used as catalysts highly effectively and selective for ROMP and RCM reactions. The invention also relates to preparation of new ruthenium catalysts and the uses in metathesis. Moreover, the invention also provides effective methods of making various functional polymers by ROMP reaction in the presence of new ruthenium catalysts.