(4aR,8R)-8-[(1R)-cyclohex-2-en-1-yl]-2-morpholin-4-yl-4a,5,8,8a-tetrahydrochromen-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: (4aR,8R)-8-[(1R)-cyclohex-2-en-1-yl]-2-morpholin-4-yl-4a,5,8,8a-tetrahydrochromen-4-one
• 化学式: C₁₉H₂₅NO₃
• 分子量: 315.4
• InChiKey: OUUQMCOITSPFDP-IJOZJFQKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] GENERATION OF PANCREATIC ENDODERM FROM PLURIPOTENT STEM CELLS USING SMALL MOLECULES<br/>[FR] GÉNÉRATION D'ENDODERME PANCRÉATIQUE À PARTIR DE CELLULES SOUCHES PLURIPOTENTES À L'AIDE DE PETITES MOLÉCULES
  申请人：NOVO NORDISK AS

  公开号：WO2014033322A1

  公开（公告）日：2014-03-06

  A method of producing pancreatic cells or pancreatic cell precursors expressing at least 5% PDX1/NKX6.1 double positive, comprising exposing definitive endoderm cells to an effective amount of one or more small molecules, to differentiate the human definitive endoderm cells into the pancreatic cells or pancreatic cell precursors. The present invention also relates to pancreatic endoderm cells produced by said methods and uses of said pancreatic endoderm cells.